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cardiovascular-abnormalities Clinical Trials

A listing of cardiovascular-abnormalities medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

Found 244 clinical trials
B Brigitte Fauroux, MD, PhD

Respiratory Muscles and Work of Breathing in Children

Respiratory muscle testing allows a quantitative assessment of inspiratory and expiratory muscles in children of any age with primary or secondary respiratory muscle impairment, in order to better understand the pathophysiology of respiratory impairment and guide therapeutic management. The use of an invasive technique (esogastric probe) makes it possible to …

- 17 years of age Both Phase N/A
P Patricia Longmuir

A Feasibility Study of Physical Activity After Surgical or Catheterization Intervention

This feasibility study will assess whether a 6-month, home-based, parent-led physical activity program, completed after surgical or catheterization treatment, enables young children with congenital heart defects (CHD) to achieve the recommended 180 minutes of daily physical activity. This study includes comprehensive measures of motor skill and physical activity, intervening at …

3 - 72 years of age Both Phase N/A

Creation of a French South-Eastern Database and DNA-bank of Congenital Heart Disease to Explore the Genetic Pathways

Congenital heart defects are seen in 0,8% of life births. In France this means more than 5000 newborns per year. The south-east region of France is particularly affected as a result of a higher birth rate and consanguinity, when compared to other regions. The majority of congenital heart diseases remain …

- 100 years of age Both Phase N/A
M Mandy Pershing, MS

Improving Patient and Family Health Using Family-Centered Outcomes and Shared Decision-Making

This study is a randomized clinical trial where participants (parents of a fetus or neonate diagnosed with a life-threatening congenital heart disease (CHD)) will randomly be assigned to either receiving a web-based decision aid (DA) alone, or receiving the decision aid that includes a values clarification exercise. Because of the …

18 - 100 years of age Both Phase N/A
Z Zakaria JALAL, MD

Safety and Efficacy Study of reSept ASD Occluder for Treating Secundum ASD

Evaluation of the safety and efficacy of the reSept ASD Occluder to treat patients with clinically significant secundum atrial septal defect

- 84 years of age Both Phase N/A
A Allan R Kluser Sales, PhD

Inspiratory Muscle Strength Training in Post-Covid Syndrome

Patients with post-Covid-19 syndrome are at high risk of developing cardiovascular diseases 12 months after acute infection of COVID-19. We recently revealed that these patients have elevated muscular sympathetic nerve activity (MSNA), vascular dysfunction, impaired cardiac diastolic function, and reduced functional capacity. Considering that these outcomes are independent predictors of …

18 - 65 years of age Both Phase N/A
A Ambra Burrell

Two-Year Study of the Safety and Efficacy of the Second-Generation Tissue Engineered Vascular Grafts

A single arm clinical trial evaluating the safety and efficacy of the second generation TEVG as vascular conduits for extracardiac total cavopulmonary connection.

- 100 years of age Both Phase 2
K Kholida B Abdurashidova

Development of Methods for Effective Treatment and Improvement of Common Somatic Diseases in Children

The goal of the clinical study is to clarify the course of common congenital, infectious, and non-infectious diseases in children living in Uzbekistan, and to develop methods for their treatment and rehabilitation. The main questions it aims to answer: Analysis of common congenital diseases among children; Analysis of commonly diagnosed …

3 - 15 years of age Both Phase N/A
A Anne Dompmartin, MD, PhD

Efficacy and Safety of Sirolimus in Vascular Anomalies That Are Refractory to Standard Care

The phosphatidylinositol 3-kinase (PI3Kinase)/Protein Kinase B (AKT)/mammalian target of rapamycin (mTor) pathway plays a role on the development and the venous/lymphatic vascular organisations. The investigators want to study the efficacy and the safety of Rapamycin, an mTor inhibitor.

3 - 70 years of age Both Phase 3

Topical Sirolimus in Cutaneous Lymphatic Malformations

Cutaneous microcystic lymphatic malformations (CMLMs) are rare conditions of children and adults resulting from abnormal embryologic development of lymphatic vessels. They present as clusters of vesicles full of lymph and blood of various extent. They ooze and bleed, inducing maceration, esthetic impairment, scars, pain, bacterial infections and impaired quality of …

6 - 100 years of age Both Phase 2

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