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mitral-valve-regurgitation Clinical Trials

A listing of mitral-valve-regurgitation medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

Found 217 clinical trials

Serotonin Receptor Blockers in Ischemic Mitral Regurgitation

This study is intended to investigate the effect of cyproheptadine (a 5HT2B receptor blocker) on mitral regurgitation severity.

18 - 80 years of age Both Phase 2
D Daniel GRINBERG, MD

Impact of Preoperative Myocardial Fibrosis Related to Mitral Valve Prolapse on Postoperative Left Ventricular Remodeling

Primary mitral regurgitation (MR) is the most common valvular disease in western countries. The MR mechanism is often related to a mitral valve prolapse (MVP) defined as a single or bi-leaflet prolapse of at least 2 mm beyond the long-axis mitral annular plane. In recent years, several studies have identified …

18 - 100 years of age Both Phase N/A
J Jian'an Wang, MD

Safety and Effectiveness Study of Dragonfly System for Functional Mitral Regurgitation

To confirm the effectiveness and safety of the Dragonfly transcatheter mitral valve repair system for the treatment of chronic moderate to severe (3+) or severe (4+) functional mitral regurgitation (FMR) who remained clinically symptomatic after guideline-directed medical treatment.

18 - 100 years of age Both Phase N/A

MRS Measurement of Glutamate and GABA Metabolism in Brain

This study will use magnetic resonance spectroscopy (MRS) to measure in the brain the transfer of [13]C as it is naturally metabolized from glucose to specific chemical transmitters. From this method, we can measure the rate of production of an important excitatory neurotransmitter (glutamate) as well as an inhibitory neurotransmitter …

18 - 65 years of age Both Phase N/A
J Jessica Morgan

Evaluating Raised Intracranial Pressure Using MR Elastography

Investigators will compare magnetic resonance (MR) elastography measurements to other forms of noninvasive methods of detecting raised intracranial pressure, including optical coherence tomography (OCT) imaging measurements of the retinal nerve fiber layer (RNFL) and indirect signs of raised intracranial pressure on magnetic resonance imaging (MRI).

18 - 100 years of age Both Phase N/A
L Leeanne Lezotte

Physiologic MR Imaging of Salivary Gland Tumors

The goal of this study is to use advanced Magnetic Resonance Imaging (MRI) techniques to help identify the difference between cancerous and non-cancerous salivary gland tumors for improving treatment strategies and to aid in the prediction of disease progression.

18 - 100 years of age Both Phase N/A
A Alejandro Berlin, MD

Prostate Cancer Subclinical Metastatic Ablative MR-guided Radiotherapy

In the clinical scenario of recurrent prostate cancer (PCa) post local therapy, current standard studies (bone scan and computed tomography) commonly fail to identify the recurrent disease location. In this study the investigator aims to prospectively map recurrent disease with the unique combination of whole-body MR anatomical imaging combined with …

18 - 100 years of age Male Phase N/A
G Gerald Choa MRI Center CUHK

Application of 3D MR Neurogram for Intraparotid Facial Nerves Evaluation

Parotid neoplasm consists of a wide range of benign and malignant lesions, and parotidectomy has been the mainstay for management of these neoplasms. Within the parotid gland there are branches of the intra-parotid facial nerves, which are tiny in calibre and are prone to injury to injury during operation. It …

18 - 100 years of age Both Phase N/A

Advanced MR Imaging as Predictor of Treatment Response in Newly Diagnosed Glioblastomas

This clinical trial studies advanced MR imaging techniques in measuring early response of standard treatment may become predictors of long-term treatment response in patients with newly diagnosed glioblastomas.

18 - 100 years of age Both Phase N/A
A Ali Hosni, MD

MR-Adaptive Radiation Therapy for Anal Cancer With EScalated-Treatment in a Risk-Optimized Approach

The proposed study is a phase II, single arm, open-label trial of MR-guided radiation therapy (RT) with risk stratified RT dose selection in patients with anal cancer. Based on previous data, a risk adaptive treatment approached is proposed in 4 groups: Low risk, standard risk, intermediate risk, and high risk. …

18 - 100 years of age Both Phase 2

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