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celiac-disease Clinical Trials

A listing of celiac-disease medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

Found 43 clinical trials
C Carin Andrén Aronsson, PhD

Prevention of Celiac Disease in Skåne

This study aims to investigate the impact on being on a gluten free diet the first three years of life compared to a daily intake of a probiotic supplementation or placebo on the risk of developing celiac disease autoimmunity or celiac disease in genetically susceptible children. Study participants will be …

4 - 4 years of age Both Phase N/A
C Charles Melbern Wilcox, MD

EUS-guided Celiac Plexus Block vs. Sham in Chronic Pancreatitis

The aim of this randomized trial is to assess the efficacy of EUS-CPB in the alleviation of abdominal pain in patients with chronic pancreatitis.

18 - 100 years of age Both Phase N/A
P Pasquale Mansueto, MD

Tolerability of an Ancient Grain in Patients With Non-Celiac Wheat Sensitivity

Patients suffering from wheat-related troubles, in absence of celiac disease or wheat allergy diagnosis, can suffer from non-celiac wheat sensitivity (NCWS). This is characterized by both gastrointestinal (GI) and extra-intestinal symptoms, which improve with the elimination of wheat intake. To date no definitive explanation of pathogenetic mechanisms of NCWS has …

18 - 65 years of age Both Phase N/A
C Christopher Barbara

ICT Tools for the Diagnosis of Autoimmune Diseases

The ITAMA project, which ended in 03/2022, came from the need to increase/anticipate the number of diagnosed cases of celiac disease (CD). The project involved the preliminary development of 'software tools' (Graphical User Interface (GUI), DATABASE, Decision Support System (DSS)) used to support the physicians to optimize CD diagnosis. Subsequently, …

12 - 100 years of age Both Phase N/A
F Federica Branchi, MD

A Study to Assess the Safety of TPM502 in Adults With Celiac Disease

The goal of this clinical trial is to learn about the safety and the pharmacodynamic (PD) effects of TPM502 in adults with celiac disease. The main questions it aims to answer are: if TPM502 is safe and well tolerated if TPM502 can induce modifications in parameters indicating that it may …

18 - 70 years of age Both Phase 2

A Study of Efficacy, Safety, and Tolerability of KAN-101 in People With Celiac Disease

The study goal is to evaluate the efficacy, safety, and tolerability of KAN-101 in participants with Celiac Disease (CeD)

18 - 70 years of age Both Phase 2

T Cell Receptor (TCR) Sequencing and Transcriptional Profiling in Adult Celiac Disease Patients Undergoing Gluten Challenge

The primary objectives are: Characterize the T cell receptor (TCR) repertoire in duodenal biopsy samples of participants pre- and post-challenge. Compare for each patient the TCR repertoire of duodenal biopsy samples with the peripheral blood TCR repertoire of each study participant Characterize the transcriptome of duodenal biopsy samples and blood …

18 - 75 years of age Both Phase N/A
J Judit Bajor, MD, PhD

Cardiovascular Risk Factors in Coeliac Disease: a Series of Studies

This investigation examines the most important cardiovascular risk factors (e.g., metabolic parameters, body composition) and their changes in coeliac disease. The series of studies allow to assess body composition and cardiovascular risk-related metabolic parameters of newly diagnosed and treated coeliac patients in their complexity and to test if they change …

18 - 100 years of age Both Phase N/A
S Sonia Kupfer, MD

Tissue Destruction and Healing in Celiac Disease

The purpose of this clinical study is to learn more about celiac disease pathogenesis and clinical symptoms. In particular, this study will examine the interactions between biological factors such as, intestinal epithelial cells, microbiota, immune system, genetics, and gluten and their effect on celiac disease clinical symptoms, and severity of …

18 - 75 years of age Both Phase N/A

Efficacy of Cholesterol-lowering L. Plantarum on Cardiometabolic Health Biomarkers in Coeliac Disease Patients

Recent studies have also shown that 30% of the world's population carries the susceptibility genes for coeliac disease and that only 2-5% of these individuals are really affected, however, studies suggest the existence of other factors capable of contributing to the onset of the disease, such as intestinal dysbiosis. We …

18 - 65 years of age Both Phase N/A

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