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Knee Injuries Clinical Trials

A listing of Knee Injuries medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

Found 100 clinical trials
K Koen Peers, MD, PhD

Immediate Versus Optional Delayed Surgical Repair for Treatment of Acute ACL Injuries

Currently, most patients with an anterior cruciate ligament injury undergo surgery. There is a general belief that surgical reconstruction is necessary to safely return to sports and to prevent early knee osteoarthritis or additional meniscus injuries. But there is insufficient scientific evidence to support this belief. Moreover, several studies show …

16 years of age All Phase N/A
M Mickel Mikhaa, resident

Augmentation of Partial Anterior Cruciate Ligament Tear: Early Results

Clinical evaluation for the patients with partial ACL tear who had ACL augmentation

15 - 50 years of age All Phase N/A
R Riann M Palmieri-Smith, PhD

Michigan Split-belt Treadmill Training Program to Improve Acute Knee Biomechanics After ACL Reconstruction

The goal of this study is to determine short-term adaptations (aftereffects) in knee loading after a 20-minute split-belt treadmill training session in patients with ACL reconstruction. Our main question for this aim are: Are training-mediated aftereffects in the knee joint moment greater for tied-belt walking or split-belt walking? Are training-mediated …

14 - 45 years of age All Phase N/A
R Richard Brull, MD

Adjuncts for Adductor Block: Dexamethasone,Dexmedetomidine, or Combination to Reduce Pain

The aim of this multi-centered study is to evaluate the effects of two distinct Adductor Canal Block (ACB) adjuncts, dexamethasone and dexmedetomidine, and their combination, on postoperative analgesia in patients undergoing Anterior Cruciate Ligament (ACL) Repair.

18 - 50 years of age All Phase 4
T Tauno Koovit

Kinesiophobia After Anterior Cruciate Ligament Reconstruction.

Anterior cruciate ligament (ACL) rupture is a serious trauma with long-term consequences to the athlete. Psychological and physiological factors may negatively affect patient recovery and increase reinjury rate after anterior cruciate ligament reconstruction (ACLR), and development of kinesiophobia is also possible.

15 - 60 years of age All Phase N/A
G Guri Ekås, PhD

How to Best Treat Anterior Cruciate Ligament Injuries

The project is a pragmatic registry-based RCT aiming to investigate ACL injury treatment. Study results will help fill knowledge gaps, facilitate shared decision making and strengthen patient treatment. Included patients will be randomized to (1) early ACL surgery followed by rehabilitation or (2) active rehabilitation with optional delayed surgery if …

16 - 50 years of age All Phase N/A
A Abbey Thomas, PhD

External Focus of Attention Feedback to Reduce Risk of Non-contact ACL Injury

Knee injuries, especially those to the ACL, are common among physically active people. Preventing these injuries from happening is critical to limiting the long-term pain, disability, and arthritis associated with these injuries. Our study is going to examine new ways to provide feedback about the way people move to determine …

18 - 35 years of age All Phase N/A
T Thomas J. Kremen, M.D.

Biologic Therapy to Prevent Osteoarthritis After ACL Injury

Anterior cruciate ligament (ACL) injuries are extremely common. On average, 50% of individuals suffering an ACL injury will develop radiographic osteoarthritis (OA) 10 to 20 years after injury. Unfortunately, ACL reconstruction does not prevent risk of future OA. Interleukin-1 (IL-1) levels in the human knee joint increase transiently after an …

18 - 35 years of age All Phase N/A
E Elvire SERVIEN, MD

ALL Reconstruction Versus Modified Lemaire's LET in Combination With ACL Reconstruction With a Minimum Follow up of 2 Years

Anterior cruciate ligament (ACL) tears are associated with concomitant lesions of the anterolateral ligament (ALL), which increase rotatory instability of the knee. If untreated, ALL insufficiency can compromise the results of ACL reconstruction, with higher risk of iterative ACL tear or additional meniscal lesion. Several surgical techniques have been described …

18 - 50 years of age All Phase N/A
C Christopher Modlesky, PhD

Steps Towards Osteoarthritis Prevention

Optimal knee joint loading, which refers to the forces acting on the knee caused by daily activities such as daily steps, plays an essential role in maintaining knee articular cartilage health and reducing the risk of osteoarthritis (OA). After anterior cruciate ligament reconstruction (ACLR), individuals take fewer daily steps as …

16 - 40 years of age All Phase N/A

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