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liver-transplantation Clinical Trials

A listing of liver-transplantation medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

Found 150 clinical trials
P Philippe Macaire, MD

Benefit of ESP Peri Operative Analgesia for Live Liver Donor Transplantation

Liver donors have a significant risk to develop persistent and chronic pain around 20 to 30% affecting social and professional life (17%) up to 1 year after the surgery. To donate a part of liver is a beautiful gift reason why the pain relief must be improved. Meta-analysis showed that …

18 - 60 years of age Both Phase N/A
M Mengyao Li, MB

Human Umbilical Cord Mesenchymal Stem Cell Transplantation for The Treatment of Acute-on-Chronic Liver Failure

This study is a randomized double-blind placebo-controlled multicenter clinical trial to evaluate the safety and efficacy of human umbilical cord mesenchymal stem cell (UC-MSC) transplantation for the treatment of acute-on-chronic liver failure (ACLF). UC-MSC therapy may improve the clinical outcomes of patients with ACLF. The trial would provide scientific evidence …

18 - 70 years of age Both Phase 1/2
G Giuseppe Remuzzi, MD

MSC Therapy in Liver Transplantation

The general aim of the present study is to test a cell therapy with third-party allogeneic ex-vivo expanded MSCs as a strategy to induce tolerance in liver transplant recipients. MSCs will be prepared accordingly to established protocols , starting from diagnostic samples of bone marrow aspirates (2-5 mL) or using …

18 - 100 years of age Both Phase 1

Impact of a LCD on Metabolic Inflexibility and Cardiovascular Risk in Liver Transplant Patients

This study is looking to see how a 6-month low carbohydrate diet can affect the body's ability to use energy in addition to the affects it has on the heart and blood vessel health.

18 - 100 years of age Both Phase N/A

Safety of DNP007 in Healthy Subjects

This clinical trial evaluated the safety, tolerability, pharmacokinetic properties, and immunogenicity of DNP007 when administered as a single dose. Since this is a phase 1 study for exploratory evaluation, to the extent that it meets the study objectives, In order to proceed with the minimum number of subjects, a total …

19 - 55 years of age Male Phase 1
M Michael Nesbitt

PRehab tO PreparE Living Liver Donors for Enhanced Recovery

to determine if a Phase III RCT of prehab vs usual care for LLDs is feasible (including rates of recruitment, adherence, adverse events, and attrition); to determine what, if any, intervention or trial modifications are warranted for a Phase III RCT; and, to explore estimates of efficacy among donor-centered outcomes …

- 100 years of age Both Phase N/A
Q Qiang Xia, MD, PhD

Pediatric Liver Transplantation-Liver Fibrosis Evaluation by Using Fibrosis Panel

Liver transplantation in children is highly successful with >80% having 20 years survival. Most pediatric liver diseases are potentially curable with liver transplantation and it is important to establish whether children who have undergone successful transplantation can expect a normal life expectancy or whether there will be a gradual decline …

2 - 18 years of age Both Phase N/A
N Nicolas GOLSE, phD

Hepatic and Systemic Hemodynamic Modeling During Liver Surgery

" Despite the medical and surgical progress of the last two decades, the selection of candidates for liver surgery remains based on old principles and insufficiently sensitive to fine-tune the gesture to patient-specific characteristics and make almost zero risks of postoperative liver failure (PLF) and death. It is therefore necessary …

18 - 100 years of age Both Phase N/A
O Olivia Geraci

Prehabilitation for Patients Awaiting Liver Transplantation

This study will assess the feasibility, safety and effectiveness of a structured prehabilitation program combining exercise training, nutritional optimization and psychological support for patients with cirrhosis awaiting liver transplantation.

18 - 100 years of age Both Phase N/A

APCext : Effect of Temporary Porto-caval Shunt During Liver Transplantation on Function of Liver Graft From Extended Criteria Donor

The success of orthotopic liver transplantation (OLT) in treatment of liver malignancy and endstage liver disease has led to an increase in the gap between patients on waiting-lists and available liver grafts. In order to compensate for this scarcity, use of liver grafts harvested from extended criteria donors (ECD) has …

18 - 100 years of age Both Phase N/A

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