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germ-cell-tumors Clinical Trials

A listing of germ-cell-tumors medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

Found 1,022 clinical trials
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Active Surveillance, Bleomycin, Etoposide, Carboplatin or Cisplatin in Treating Pediatric and Adult Patients With Germ Cell Tumors

This phase III trial studies how well active surveillance help doctors to monitor subjects with low risk germ cell tumors for recurrence after their tumor is removed. When the germ cell tumor has spread outside of the organ in which it developed, it is considered metastatic. Drugs used in chemotherapy, …

- 100 years of age Both Phase 3
S Sandeep Batra

A Study of a New Way to Treat Children and Young Adults With a Brain Tumor Called NGGCT

This phase II trial studies the best approach to combine chemotherapy and radiation therapy (RT) based on the patient's response to induction chemotherapy in patients with non-germinomatous germ cell tumors (NGGCT) that have not spread to other parts of the brain or body (localized). This study has 2 goals: 1) …

3 - 29 years of age Both Phase 2
F Ferdinando Cananzi, MD

Sacral Chordoma: Surgery Versus Definitive Radiation Therapy in Primary Localized Disease

Comparative study on surgery versus definitive radiation therapy in primary localized sacral chordoma

18 - 80 years of age Both Phase N/A
M Mauricette MICHALLET, MD

A Post-treatment Program to Identify and Manage Complications Related to Oncology or Hematology Treatments in Cancer Survivors.

INTRODUCTION: Approximately 44% of cancer survivors experience a deteriorated quality of life 5 years after diagnosis due to late onset of complications related to cancer treatments. The objective of the study is to evaluate the incidence rates of treatment-related complications, identify sub-clinical abnormalities and risk factors in patients participating in …

18 - 65 years of age Both Phase N/A

Phase 1, Safety and Tolerability Study of XmAb®541 in Advanced Solid Tumors

The primary purpose of this study is to determine whether the investigational drug XmAb541 is safe and well tolerated, and to determine an optimal and safe dose(s) for further study. The study will also evaluate effect of XmAb541 on tumor outcomes.

15 - 100 years of age Both Phase 1

A Study of HFB200301 as a Single Agent and in Combination With Tislelizumab in Adult Patients With Advanced Solid Tumors

The purpose of this study is to test the safety and tolerability of HFB200301 as a single agent and in combination with tislelizumab in patients with advanced cancers. There are two parts in this study. During the escalation part, groups of participants will receive increasing doses of HFB200301 as a …

18 - 100 years of age Both Phase 1

A Study of DS-9606a in Patients With Advanced Solid Tumors

This study will assess the safety and tolerability of DS-9606a in patients with advanced solid tumors.

18 - 100 years of age Both Phase 1
C Christin Snow, RN

Maintenance Oral Etoposide or Observation Following High-dose Chemo for GCT

This is an open label randomized phase II trial of maintenance oral etoposide vs. observation in patinets with relapsed GCT treated with high-dose chemotherapy (HDCT) and peripheral-blood stem-cell transplant (PBSCT).

18 - 100 years of age Both Phase 2
C Christin Snow, RN

A Phase II Trial of Cabozantinib With Patients With Refractory GCTs

The purpose of the CTO-IUSCCC-0752 study is to investigate the use of Cabozantinib for patients with incurable, refractory germ cell tumors. Patients will be treated until evidence of disease progression, non-compliance with study protocol, unacceptable major toxicity, at subject's own request for withdrawal, or if the study closes for any …

- 100 years of age Both Phase 2

Vorinostat in Combination With Chemotherapy in Relapsed/Refractory Solid Tumors and CNS Malignancies

Investigators are testing new experimental drug combinations such as the combination of vorinostat, vincristine, irinotecan, and temozolomide in the hopes of finding a drug that may be effective against tumors that have come back or that have not responded to standard therapy. The goals of this study are: To find …

1 - 30 years of age Both Phase 1

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