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seizure-disorders-pediatric Clinical Trials

A listing of seizure-disorders-pediatric medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

Found 10 clinical trials

A Study to Evaluate Efficacy and Safety of Perampanel Administered as an Adjunctive Therapy in Pediatric Participants With Childhood Epilepsy

The purpose of the study is to evaluate the efficacy of perampanel as measured by the 50 percent (%) responder rate during the maintenance period of the core study for seizure frequency in participants with pediatric epileptic syndrome (Cohort 1) and partial-onset seizures (POS) (Cohort 2).

1 - 18 years of age Both Phase 2
S Shao-Yu Tsai

Getting SMART for Pediatric Epilepsy

The purpose of this study is to evaluate the effect of melatonin for improving sleep in pediatric epilepsy.

1 - 18 years of age Both Phase 2/3
D Damien JOLLY

Social Cognition in Pediatric Epilepsy

The purpose of this study is to investigate the development of social cognition skills in pediatric epilepsy compared to healthy children. There are evidences indicating that children with epilepsy have executive dysfunctions and language problems. Executive functions refer to multiple cognitive processes that contribute to human higher order abilities, such …

6 - 12 years of age Both Phase N/A
D Dongfang Li

Ketogenic Diet in Pediatric Intractable Epilepsy

This study aims to evaluate the efficacy of a ketogenic diet in treating pediatric intractable epilepsy and to explore its relationship with changes in inflammatory markers. The investigators plan to recruit 59 participants with intractable epilepsy, 39 of whom will receive a combination of ketogenic diet and conventional antiepileptic drugs, …

6 - 12 years of age Both Phase N/A
C Clinical Trials Unit

Epidiolex® for Anxiety in Pediatric Epilepsy

This is a prospective open label study assessing the efficacy and tolerability of pharmaceutical grade cannabidiol--Epidiolex (R), for the treatment of anxiety in pediatric patients with pediatric epilepsy that has been difficult to treat and requires ongoing use of anticonvulsant medication.

6 - 17 years of age Both Phase 4
E Eishi Asano, MD, PHD

Diffusion MRI Methods to Minimize Postoperative Deficits in Pediatric Epilepsy Surgery

This project will test the accuracy of a novel diffusion-weighted magnetic resonance imaging (DWMRI) approach using a deep convolutional neural network (DCNN) to predict an optimal resection margin for pediatric epilepsy surgery objectively. Its primary goal is to minimize surgical risk probability (i.e., functional deficit) and maximize surgical benefit probability …

3 - 19 years of age Both Phase N/A
M Manish N Shah, MD

Diffusion Tensor and Functional Connectivity Imaging in Pediatric Epilepsy: Imaging/Histology Correlation

To determine the utility of diffusion tensor magnetic resonance imaging in the preoperative workup of children with intractable epilepsy referred for surgery.

- 18 years of age Both Phase N/A
R Roberto Previtali, MD

Effectiveness and Impact on the Quality of Life of Ketogenic Diet in Pediatric Patients

The goal of this observational study is to learn about the clinical and nutritional effectiveness of ketogenic diet (KD) in pediatric patients with genetic, neurological or metabolic conditions requiring KD. The main question[s] it aims to answer are: does KD support adequate growth? does KD improve clinical symptoms? how does …

- 18 years of age Both Phase N/A
B Baptiste Morel

Optimized Volumetry in Radiology: Interest in Pediatric Brain MRI in the Exploration of Focal Epilepsy

Multicentre cross-sectional study with prospective recruitment comparing the detection rate of lesions on brain MRI without and with quantitative volumetry and T1 relaxometry information during the management of children with suspected focal epilepsy.

1 - 18 years of age Both Phase N/A
A Amelie ya

RESting-state Functional MRI for Prediction of Post-surgical Prognosis In Pediatric Drug-Resistant Epilepsy

Resting-state functional MRI (r-fMRI) has emerged in recent years to analyze resting networks. It allows, without active participation of the patients, to identify and analyze the different functional brain networks. The analysis of r-fMRI can be done thanks to the graph theory, which is based on the based on the …

6 - 18 years of age Both Phase N/A

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