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pleural-effusion Clinical Trials

A listing of pleural-effusion medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

Found 30 clinical trials

The Effectiveness and Safety of Ultrasound Elastography Guided Pleural Biopsy in the Differential Diagnosis of Benign and Malignant Pleural Effusion

The goal of this clinical trial is to evaluate the diagnostic effcacy and safety of ultrasound elastography guided pleural biopsy in the differential diagnosis of benign and malignant pleural effusion. The main question it aims to answer are: the effectiveness and safety of ultrasound elastography guided pleural biopsy in the …

18 - 90 years of age Both Phase N/A
L Lonny Yarmus

Gravity Versus Vacuum Based Indwelling Tunneled Pleural Drainage System

Malignant pleural effusion remains a debilitating complication of end stage cancer, which can be greatly improved by the introduction of the indwelling tunneled pleural catheter (IPC). However, there is no standard of care regarding drainage and limited data on the utility of different drainage techniques. In addition, many patients develop …

18 - 100 years of age Both Phase N/A
I Israel Aharony, M.D Ph.D.

Diagnosis and Classification of Pleural Diseases Using Ultrasound Channel Data

Background The Pleura is a double-layered membrane that surrounds the lungs. Pathological processes that involve the Pleura are called "Pleural diseases". Among them are included Pneumothorax (Air the chest cavity), Pleural effusions, and tumor formation. Ultrasound imaging of the Pleura to detect and assess pleural diseases has been proven as …

18 - 100 years of age Both Phase N/A

Clinical Validation of Programmable Drain Fluid Regulator to Reduce Morbidity, Care Requirements, and Improve Outcomes

The goal of this Effidrain first-in-human medical device trial is to improve the outcomes of patients with pleural effusions and ascites. The main aims are: The primary aim of this first-in-man device pivotal study (n=120) is to demonstrate that the body fluid drain regulator can perform the function of pleural …

21 - 100 years of age Both Phase N/A
M Martin Graversen, MD

OPC5: Pressurized IntraThoracic Aerosol Chemotherapy (PITAC) in Patients With Malignant Pleural Effusion.

This study will monitor and evaluate patient and personnel safety and toxicity during the implementation and evaluation of Pressurized IntraThoracic Aerosol Chemotherapy (PITAC) directed treatment. Furthermore, this study will focus on Quality of Life questionnaires, LENT score, and evaluate pain and breathlessness using af visual analogue scales (VAS).

18 - 100 years of age Both Phase 1

Thoracentesis to Alleviate Cardiac Pleural Effusion

The present study will examine the comparative effectiveness of two treatment strategies currently used in the treatment of patients with systolic heart failure presenting with pleural effusion. Patients will be randomized to standard medical treatment only or medical treatment and referral to thoracentesis. Study hypothesis: A strategy of referring patients …

18 - 100 years of age Both Phase N/A

Strategy for Prompt and Effective Thoracentesis in the Emergency Department

The SPEEDTAP-trial is a prospective, randomised, investigator-initiated, multicenter, clinical superior trial investigating two thoracentesis methods in four emergency departments (ED) in Central Denmark Region. Patients are randomised to either manual fluid removal in the ED or passively fluid drainage using gravity in the radiology department (standard of care). Primary outcome: …

18 - 100 years of age Both Phase N/A
K Kareem Ahmed Hosny, Bachelor of medicine

Video Assisted Thoracoscopic Surgery (VATS) - Surgical Pleurodesis vs Tube Drainage in Management of Malignant Pleural Effusion (MPE)

Malignant Pleural Effusion (MPE) is considered to be a common presentation at malignant tumors representing 15% of all cancer cases. It carries a burden on our patients with dyspnea being the most common symptom in most of cases. Management of symptomatic malignant pleural effusion remains to be a point of …

5 - 90 years of age Both Phase N/A
Y YC Gary Lee, MBChB PhD

AMPLE-3: IPC Plus Talc vs VATS in Management of Malignant Pleural Effusion

The purpose of this study is to determine if an indwelling catheter is more effective than surgical pleurodosis in treating malignant pleural effusion. Who is it for? You may be eligible for this study if you are an adult who is suffering from symptomatic proven pleural malignancy or an otherwise …

18 - 100 years of age Both Phase N/A
K Ka Yan Chiang, MBBS(HK)

Comparing Different Sizes of Small-bore Chest Drains in Malignant Pleural Effusion

Malignant pleural effusion (MPE) is a very common medical condition, especially among patients with disseminated cancers. Chest drain insertion aims to drain the pleural fluid collection and relieve dyspnea. Small bore chest tubes are recommended as the first line therapy for draining pleural effusions. However, there is no clinical data …

18 - 100 years of age Both Phase N/A

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