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histiocytoma Clinical Trials

A listing of histiocytoma medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

Found 8 clinical trials
P Pamela Sloan, RN, CCRP

A Study to Evaluate the Utilization of 3D Printed Models in Pre-Operative Planning

This prospective, multi-center, randomized controlled study aims to assess the efficacy of utilizing 3D printed models in preoperative planning for the excision of tumors involving bony structures within the body. The study is expected to last approximately 12 months and involve up to 150 subjects across 3 sites. Subjects will …

22 - 100 years of age Both Phase N/A
L Louise Magat

Focused Ultrasound to Promote Immune Responses for Undifferentiated Pleomorphic Sarcoma

This study is a single site, single-arm, feasibility study to evaluate the safety and efficacy of MRgFUS using the ExAblate 2100 System for the partial ablation of undifferentiated pleomorphic sarcomas.

18 - 100 years of age Both Phase N/A
M Mohammed Milhem, MBBS

Palbociclib and Pembrolizumab in Undifferentiated Pleomorphic Sarcoma (UPS)

This is a single-arm open-label window of opportunity clinical study assessing the impact of pre-treatment with palbociclib.

12 - 100 years of age Both Phase 1
N Niels Junker, MD, PhD

Propranolol and Pembrolizumab in Advanced Soft Tissue Sarcoma Patients

The goal of this phase 2 clinical trial is to test efficacy and tolerability of combining propranolol and pembrolizumab in patients with advanced angiosarcoma or undifferentiated pleomorphic sarcoma. The main questions aims to answer: Primary: determine the progression-free survival rate (PFSR) at 3 months Secondary: determine the objective response rate …

18 - 100 years of age Both Phase 2
P Pierre Fournel, MD

Efficacy and Safety of Regorafenib as Maintenance Therapy After First-line Treatment in Patients With Bone Sarcomas

This is a randomized, double-blinded, 2 arms study concerning patients with bone sarcoma after the first line therapy. In the first arm, patients will be treated with regorafenib for a maximum of 12 months as maintenance therapy after first line therapy, whereas in the second arm, patients will be treated …

12 - 100 years of age Both Phase N/A

A Study of Pembrolizumab Plus Local Chemotherapy Using Isolated Limb Infusion (ILI) for Patients With Sarcoma in the Arm or Leg

The purpose of this study is to find out whether giving the study drug pembrolizumab in combination with the chemotherapy drugs melphalan and dactinomycin, delivered directly to the affected arm or leg using a technique called isolated limb infusion (ILI), is a safe treatment that can delay the time before …

12 - 100 years of age Both Phase 2
F Florence DUFFAUD

Combination of Pembrolizumab and Cabozantinib in Patients With Advanced Sarcomas

Phase II trial with three independent strata to independently assess the effects of the association of pembrolizumab and cabozantinib in advanced sarcomas.

18 - 100 years of age Both Phase 2
A Antoine ITALIANO, MD,PhD

Prospective Identification of Predictive Biomarkers of Trabectedin Efficacy in Non-L Soft-tissue Sarcoma Patients

This is a biology driven, monocentric study, designed to identify biomarkers of activity of trabectedin in patients with advanced non-L soft-tissue sarcoma. The aim of this study is to implement high-throughput profiling technologies to identify predictive biomarkers of trabectedin efficacy through sequential tumor biopsies and blood sample collection in sarcoma …

18 - 100 years of age Both Phase N/A

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