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perimenopause Clinical Trials

A listing of perimenopause medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

Found 6 clinical trials

Melatonin Use in Patients With Climacterious Symptoms in the Perimenopause

Menopause is defined as the absence of menstruation for 12 months without a pathological cause and it is marked by physical fluctuations and biological changes that can impact women's quality of life. During the perimenopause and menopause transition period, women may experience a variety of changes, including menstrual cycle irregularity …

45 - 100 years of age Female Phase 2
D Dr Amjad Khan, DPhil

Effects of a Standardised Saffron Extract Supplementation on Symptoms Associated With Perimenopause in Healthy Women

The aim of the present study is to assess the effects of a normalised saffron extract supplementation, which is an extract of the flower Crocus sativus, on perimenopausal symptoms.

40 - 55 years of age Female Phase N/A
M Megan M Wenner, PhD

Impact of Estradiol on Endothelial Function in Peri-Menopausal Women

The purpose of this study is to identify the impact of estradiol (E2) on the mechanisms that regulate vascular endothelial function in peri-menopausal (PERI) women. This study is the first step in understanding factors contributing to endothelial dysfunction in women with advancing reproductive age and in response to E2 administration.

40 - 58 years of age Female Phase 4
E Emine Akar, BS

A Neurosteroid Intervention for Menopausal and Perimenopausal Depression

HYPOTHESIS Pregnenolone administration will be associated with greater reduction in depressive symptom severity than placebo in women with current mMDD. STUDY AIMS: Primary Aim: Determine if pregnenolone is associated with greater reduction in depressive symptom severity than placebo in women with mMDD, as measured by MADRS. Secondary Aims: Determine if …

40 - 67 years of age Female Phase 1/2
F For more information at the NIH Clinical Center contact Office of Patient Recruitment (OPR)

Effects of an ER Beta Agonist (Lilly Compound LY500307) on Estradiol-Withdrawal-Induced Mood Symptoms in Women With Past Perimenopausal Depression

Background Some women who had depression in the perimenopause may have mood symptoms again if they stop estrogen therapy. Estrogen acts in the brain and other tissues by binding to at least three types of estrogen receptors. One of these receptors, estrogen receptor beta may affect anxiety and depression. The …

45 - 65 years of age Female Phase 2
A Agni Pantou, M.D

Autologous Platelet Rich Plasma (PRP) Intra Ovarian Infusion in Perimenopausal Women

Autologous PRP intra ovarian infusion may improve ovarian response and women's hormonal profile and may promote folliculogenesis in perimenopausal women.

40 - 50 years of age Female Phase 2/3

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