Advanced Filters
noise

substance-abuse Clinical Trials

A listing of substance-abuse medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

Found 552 clinical trials
J James G Murphy, Ph.D.

Behavioral Economic and Wellness-based Approaches for Reducing Alcohol Use and Consequences Among Emerging Adults

The purpose of this study is to evaluate an intervention approach for non-student emerging adults that attempts to reduce alcohol use by decreasing stress and increasing engagement in positive and goal-directed activities that provide meaningful alternatives to alcohol use.

18 - 29 years of age Both Phase N/A
D David Chester, PhD

Genetic and Neural Factors in Alcohol-Related Cognition

This study is about how genetic and brain factors impact cognitive processes and behavior after alcohol consumption. Participation in this project will contribute to a better understanding of biological factors that influence alcohol misuse. This study will be completed in two laboratory visits.

21 - 45 years of age Both Phase N/A

Individualized Neuromodulation for the Core Clinical Features of Drug Addiction

Using specific EEG biomarkers in methamphetamine-dependent individuals, this study systematically probes closed-loop tACS based on brain states, assessing dosage, neurologic and behavioral effects, while comparing its efficacy with traditional open-loop tACS methods.

18 - 60 years of age Both Phase N/A
M Michael J Gawrysiak, PhD

Mindfulness-Based Relapse Prevention to Improve Medication Assisted Treatment Adherence and Drug-use Outcomes for Opioid Use Disorder

This proposal aims to determine whether an adjunctive Mindfulness-Based Relapse Prevention (MBRP) treatment program improves Medication Assisted Treatment (MAT) adherence and reduces drug-use among opioid use disorder (OUD) patients. The broad long-term objectives of this project are to investigate how integrative pharmacological and behavioral treatments improve OUD treatment outcomes. Participants …

18 - 100 years of age Both Phase N/A

Drug-Drug Interaction and Safety of AZD4041 Study (Part 1) and Efficacy, Safety, Pharmacokinetics and Pharmacodynamics of AZD4041 Study in Opioid Use Disorder (Part 2).

The purpose of the study is to assess drug-drug interaction (DDI) and safety of AZD4041 and itraconazole in healthy participants (Part 1), and to assess efficacy, safety, pharmacokinetics (PK) and pharmacodynamics (PD) of AZD404 when administered with buprenorphine/buprenorphine + naloxone in participants with moderate to severe opioid use disorder (OUD)

18 - 65 years of age Both Phase 2
M Morris D Bell, PhD

Impact of Work Activity on SUD Outcomes

To date, there are no studies of the therapeutic effects of varied work-focused programs in Veterans undergoing outpatient substance use disorder (SUD) treatment. The investigators propose a randomized clinical trial to test the effects of work-focused programs on improving sobriety and other clinical outcomes in Veterans early in the course …

18 - 100 years of age Both Phase N/A
A Alaina Geoff

Motivational Interviewing at Intake vs Intake as Usual on Client Engagement in Addiction Treatment

This K23 study is an effectiveness-implementation hybrid type I design to determine the effectiveness of Motivational Interviewing at Intake (MII), relative to intake-as-usual on client engagement and mechanisms of engagement among adults seeking outpatient addiction treatment. We also will obtain personnel feedback on the feasibility of implementing MII into standard …

18 - 100 years of age Both Phase N/A
M Michael J Li, PhD

Expression of Stress Markers During Meth Treatment (EXPRESS+)

This is a non-randomized behavioral trial that aims to investigate whether changes in inflammatory and type I IFN expression coincide with changes in methamphetamine use and viral load over the course of 12 weeks in HIV-positive people assigned male at birth with and without methamphetamine use disorder.

18 - 45 years of age Male Phase N/A
L Laura Holt, PhD

Preventing Prescription Stimulant Diversion and Medication Misuse Via a Web-Based Simulation Intervention

Half or nearly half of college students with prescriptions divert their stimulant medication, and a similarly high percentage misuse their medication or use someone else's prescription. Diversion may lead students to go without needed medication to mitigate their symptoms, increasing their risk for unintentional injuries and substance use. Further, diversion …

17 - 25 years of age Both Phase N/A
B Ben Baron

Preventing Impaired Driving Among Adolescents

The primary goal of this project is to evaluate the efficacy of webCHAT, a single-session web-intervention, on reducing impaired driving among adolescents receiving behind-the-wheel training at driver education programs.

15 - 17 years of age Both Phase N/A

Rewrite in simple language using AI