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amyotrophic-lateral-sclerosis-als Clinical Trials

A listing of amyotrophic-lateral-sclerosis-als medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

Found 141 clinical trials
J Judith Newton

Motor Neurone Disease - Systematic Multi-Arm Adaptive Randomised Trial

MND-SMART is investigating whether selected drugs can slow down the progression of motor neurone disease (MND) and improve survival. The study is 'multi-arm' meaning more than one treatment will be tested at the same time. The trial started with 3 arms; drug 1 (memantine), drug 2 (trazodone) and placebo (dummy …

18 - 100 years of age Both Phase 2/3

A Study of TCD601 (Siplizumab) in Newly Diagnosed Adult Amyotrophic Lateral Sclerosis (ALS) Patients

The purpose of this study is to investigate the safety, pharmacokinetics (PK), and pharmacodynamics (PD) of TCD601 (siplizumab) in newly diagnosed adult ALS patients.

18 - 80 years of age Both Phase 1

Polysomnographic Titration of Non-invasive Ventilation in Motor Neurone Disease

A two-arm, individual participant randomised controlled, assessor-blinded trial in 7 MND care centres across Australia will be undertaken.

18 - 100 years of age Both Phase N/A
S Shahram ATTARIAN, Pr

Tools for Therapeutic Evaluation in Charcot-Marie-Tooth Disease Type 1A: Outcome Measures and Biomarkers

This is a 2-year follow-up study of a cohort of 60 CMT1A patients. The objective is to identify markers allowing to better understand the phenotypic variability observed on patients with CMT1A, to identify predictive markers of the disease's progression and to provide validated measurement tools that can be used as …

18 - 70 years of age Both Phase N/A
J Julia Prascak, BS

Adenosine 2A Receptor Antagonism and AIH in ALS

The purpose of this research study is to determine the effects of a medication, istradefylline, in conjunction with breathing air with reduced oxygen for short periods of time (called acute intermittent hypoxia, or AIH), on breathing. This project will study breathing in people with amyotrophic lateral sclerosis (ALS) and unaffected, …

21 - 80 years of age Both Phase 1/2
A Andrew Geronimo, PhD

Remote Pulmonary Function Testing and Nurse Coaching in ALS

Comparison of respiratory outcomes in patients receiving telemedicine-guided remote pulmonary function testing (rPFT) with or without the additional support of nurse coaching. This is a randomized controlled study which assesses the effects rPFT and coaching on respiratory outcomes and quality of life.

18 - 100 years of age Both Phase N/A
N Nikita Lamaire

Platform Trial to Assess the Efficacy of Multiple Drugs in Amyotrophic Lateral Sclerosis (ALS)

The objective of this phase III, placebo-controlled platform study is to investigate the efficacy of drugs for patients with ALS (Amyotrophic lateral sclerosis).

18 - 100 years of age Both Phase 3
T Thomas Lambert, MD

Triumeq in Amyotrophic Lateral Sclerosis

To determine if Triumeq improves survival in Amyotrophic Lateral Sclerosis (ALS) compared with placebo

18 - 100 years of age Both Phase 3
A Albert C Ludolph, MD, Prof.

A Study to Evaluate, Safety, Tolerability, Pharmacodynamic (PD) Markers and Pharmacokinetics (PK) of AP-101 in Participants With Amyotrophic Lateral Sclerosis (ALS)

The purpose of this study is to evaluate the safety, tolerability, PK, and PD of AP-101 in participants with fALS and sALS.

18 - 100 years of age Both Phase 2

FUSION: A Study to Evaluate the Efficacy, Safety, Pharmacokinetics and Pharmacodynamics of ION363 in Amyotrophic Lateral Sclerosis Participants With Fused in Sarcoma Mutations (FUS-ALS)

The primary purpose of this study is to evaluate the efficacy of ION363 on clinical function and survival in carriers of fused in sarcoma mutations with amyotrophic lateral sclerosis (FUS-ALS).

10 - 100 years of age Both Phase 3

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