Overview

APOLO-VT aims to evaluate the feasibility, safety, and clinical impact of an integrated multimodal mapping workflow combining non-invasive structural and functional substrate characterization using Volumetric Electrocardiographic Imaging (ECGi) with invasive Electroanatomical Mapping (EAM) to support Ventricular tachycardia (VT) ablation targeting and verification.

Eligibility

Inclusion criteria

• Age ≥18 years.
• Diagnosis of structural heart disease (ischemic or non-ischemic cardiomyopathy).
• Documented sustained monomorphic VT (clinical or inducible), or recurrent ICD therapies for VT.
• Scheduled for catheter ablation of VT according to current international guidelines.
• Ability to provide written informed consent.
• Ability to remain upright or seated to allow a video for 3D torso reconstruction for ECGi acquisition.

Exclusion criteria

• Age \<18 years.
• Pregnant or breastfeeding women.
• Inability to provide informed consent due to physical or mental condition.
• Contraindication to computed tomography or cardiac magnetic resonance (magnetic resonance imaging-incompatible devices, claustrophobia).
• Contraindication to contrast agents (gadolinium allergy or severe renal dysfunction with estimated glomerular filtration rate \<30 mL/min/1.73 m²).
• Inability to remain upright for torso 3D reconstruction required for ECGi.
• Life expectancy \<1 year due to non-cardiac comorbidity.