Overview
The goal of NEOPRO-SIT is to establish and evaluate a neoadjuvant prehabilitation program comprised of targeted exercise therapy and structured psycho-oncological support in patients with solid tumors.
The main question is:
Will targeted exercise therapy and structured psycho-oncological support increase both physical and psychological capacity as well of quality of life compared to standard of care in a prehabilitation setting?
Researchers will:
compare a prehabilitation program to standard of care
Participants will:
receive either standard or care or a comprehensive prehabilitation program
Description
The project NEOPRO-SIT aims to establish and evaluate a neoadjuvant prehabilitation program comprised of targeted exercise therapy and structured psycho-oncological support in patients with solid tumors.
NEOPRO-SIT is a prospective, two-arm, controlled, single-center interventional study evaluating the effectiveness of neoadjuvant prehabilitation in patients with solid tumors. The study compares the standard of care with a structured, closely supervised prehabilitation program. A total of 125 patients will be enrolled in this study.
The NEOPRO-SIT project evaluates whether a structured, supervised prehabilitation program during neoadjuvant therapy provides additional physical and psychological benefits compared with a low-resource consultation-based approach. Despite the limitations of a sequential non-randomized design, the study aims to establish a feasible, standardized prehabilitation concept that could improve patient outcomes and support more efficient integration of supportive care into routine oncology.
Eligibility
Inclusion Criteria:
- Patients with solid tumors (focus on breastcancer)
- Curative-intent multimodal treatment concept with local surgical or radiotherapeutic ablation
- Working age and \> 18 years
- ECOG 0-2
- Sufficient language skills to understand questionnaires/training instructions
Exclusion Criteria:
- Severe cardiac or pulmonary comorbidities that do not allow participation in the program
- Medical contraindications for physical activity
- Lack of patient capacity to consent
- Pregnancy/breastfeeding
- Acute infections/fever
- Participation in another clinical intervention study