Overview
Islet transplantation is associated with drastically improvement glucose control in people with type 1 diabetes. This treatment resulted in the disappearance of severe hypoglycemic events. However, its long-term effectiveness is limited by progressive loss of graft function. Currently, there is no standardized method to detect early dysfunction of the transplanted islets.
This study aims to determine whether a parameter derived from continuous glucose monitoring (CGM), Time in Tight Range (70-140 mg/dL), is associated with pancreatic islet grafts function.
The study hypothesis is that a decrease in Time in Tight Range reflects early loss of islet graft function.
Eligibility
Inclusion Criteria:
- ≥18 years old
- Insulin-dependent diabetes (type 1 diabetes, secondary to chronic pancreatitis, MODY, cystic fibrosis)
- Patient who has completed a full cycle of pancreatic islet transplantation, either:
- Islet Transplantation Alone (ITA), or
- Islet After Kidney (IAK), or
- Simultaneous Islet Kidney (SIK), with \>10,000 IEQ/kg of recipient body weight, or \<10,000 IEQ/kg but having achieved insulin independence
- Patient who has provided consent for reuse of their data for this research
Exclusion Criteria:
- Patient refusal to wear continuous glucose monitoring device
- Pancreatic islet autotransplantation
- Inability to provide informed consent (e.g., difficulties understanding study information)
- Patient under judicial protection (safeguard of justice)
- Patient under guardianship or curatorship