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OPTIMISE-CKD Study_Dapagliflozin Effectiveness in CKD

OPTIMISE-CKD Study_Dapagliflozin Effectiveness in CKD

Recruiting
18-130 years
All
Phase N/A

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Overview

This is a retrospective, observational study, using secondary data captured in electronic health records (EHRs). The study is a part of the OPTIMISE-CKD program to assess the current CKD treatment landscape, Dapagliflozin utilisation and characterization of incident CKD patient and the burden of disease within an observation period of 39 months (August 2020-November 2024) in two cohorts (preand post-reimbursement of Dapagliflozin for CKD)

Eligibility

Inclusion Criteria:

  • Meets CKD definition criteria: having at least two eGFR measures ≤60 ml/min/1.73m2 measured ≥90 to 730 days apart and/or UACR ≥ 30 mg/g, and/or at least one measurement indicative of proteinuria (or with proteinuria ERA-ICD code) or CKD code.
  • Age ≥18 years.
  • 12 months continuous enrolment in the data base prior to index
  • 12 months continuous enrolment in the data base after index date.

Exclusion Criteria:

  • T1DM on or before index date.
  • Diagnosis of gestational diabetes mellitus on or before index date

Study details
    Chronic Kidney Disease

NCT07450820

AstraZeneca

13 May 2026

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