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Study Protocol: Impact of Metamizole (Optalgin®) on Anti-Xa Concentrations in Oncology Patients Receiving DOACs

Study Protocol: Impact of Metamizole (Optalgin®) on Anti-Xa Concentrations in Oncology Patients Receiving DOACs

Recruiting
18 years and older
All
Phase N/A
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Overview

Evaluation of the Effect of metamizole (Optalgin®) on Anti-Xa Levels in Oncology Patients Receiving Direct Oral Anticoagulants (DOACs)

Description

Evaluation of the Effect of metamizole (Optalgin®) on Anti-Xa Levels in Oncology Patients Receiving Direct Oral Anticoagulants (DOACs)

Eligibility

Inclusion Criteria:

  • Adult oncology patients (≥18 years old).
  • Receiving apixaban or rivaroxaban for anticoagulation.
  • New/current metamizole users taking at least 1g TID for pain management.
  • Platelets ≥100×10⁹/L
  • ECOG PS\<3
  • Provided informed consent

Exclusion Criteria:

  • History of allergic reaction to metamizole or DOACs.
  • Individuals with significant gastrointestinal disorders that may affect absorption, including (but not limited to) diagnosed bowel obstruction, persistent diarrhea, or the presence of a nasogastric tube (NGT/zonda)

Study details
    Oncologic Diseases
    Coagulation Defect
    Pain Management

NCT07384013

Rambam Health Care Campus

26 February 2026

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