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Stimulation of External Carotid Artery Circulation

Stimulation of External Carotid Artery Circulation

Recruiting
18 years and older
All
Phase N/A

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Overview

This study is testing a new approach to help people with migraine headaches. Researchers want to find out if using electrical stimulation to affect blood flow in the external carotid artery is safe and practical for helping control headaches.

The goal of the study is to determine whether this approach could improve headache symptoms and overall outcomes for people with migraines.

Eligibility

Inclusion Criteria:

  • Age ≥18
  • Chronic migraine or status migrainosus, or craniofacial pain refractory to maximal medical therapy who are undergoing MMA IA lidocaine infusion.
  • Subject has provided informed consent.

Exclusion Criteria:

  • Known allergies to lidocaine
  • Seizure disorder, history of seizures, or increased seizure susceptibility
  • Intracranial vascular malformations or dural AVF
  • Hemodynamic instability, any condition where brief hemodynamic shifts may pose risk
  • Previous MMA intervention or craniotomy that could result in MMA occlusion
  • Any implanted electronic device (pacemaker, ICD, DBS, VNS, cochlear implant, spinal cord stimulator)
  • Significant cardiovascular disease (unstable angina, severe arrhythmias, recent MI)
  • Severe autonomic dysfunction
  • Active systemic infection
  • Vulnerable populations (i.e. pregnant individuals, children, prisoners, individuals lacking decision-making capacity, persons with cognitive impairment, those unable to provide informed consent)

Study details
    Migraine

NCT07402954

The University of Texas Medical Branch, Galveston

26 February 2026

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FAQs

Learn more about clinical trials

What is a clinical trial?

A clinical trial is a study designed to test specific interventions or treatments' effectiveness and safety, paving the way for new, innovative healthcare solutions.

Why should I take part in a clinical trial?

Participating in a clinical trial provides early access to potentially effective treatments and directly contributes to the healthcare advancements that benefit us all.

How long does a clinical trial take place?

The duration of clinical trials varies. Some trials last weeks, some years, depending on the phase and intention of the trial.

Do I get compensated for taking part in clinical trials?

Compensation varies per trial. Some offer payment or reimbursement for time and travel, while others may not.

How safe are clinical trials?

Clinical trials follow strict ethical guidelines and protocols to safeguard participants' health. They are closely monitored and safety reviewed regularly.
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