Image

Preliminary Efficacy Trial of a Digital Intervention for Depression and Cannabis Use

Preliminary Efficacy Trial of a Digital Intervention for Depression and Cannabis Use

Recruiting
18 years and older
All
Phase N/A
  • Technical (Original)
  • Simplified (AI rewritten)

Powered by AI

Overview

The purpose of this study is to examine the feasibility, acceptability, and preliminary efficacy of a digital intervention for co-occurring cannabis use and depression. Participants will be randomized to complete Amplification of Positivity - Cannabis Use (AMP-C) or symptom tracking. The main outcomes will include changes in depressive symptoms and cannabis use, as well as usability ratings.

Eligibility

Inclusion Criteria:

  • Aged ≥ 18 years
  • Resides in the United States
  • Able to read and understand English and willing to provide informed consent/comply with the study protocol
  • Moderate depressive symptom severity, as indicated by the Patient Health Questionnaire-9 (PHQ-9)
  • Problematic cannabis use, as indicated by the Cannabis Use Disorder Identification Test - Revised (CUDIT-R)
  • Current elevated anhedonia, as indicated by the PHQ-9
  • Interest in receiving treatment for their cannabis use and depression
  • Meet criteria for current MDD and CUD per the DSM-5

Exclusion Criteria:

  • History of a psychotic disorder or bipolar disorder type I/II
  • Active suicidal ideation or intent based on the Columbia-Suicide Severity Rating Scale
  • Current psychotherapy engagement
  • Changes in psychotropic medication within six weeks of the start of study

Study details
    Depression - Major Depressive Disorder
    Cannabis Use Disorder
    Mental Disorder

NCT06878859

Massachusetts General Hospital

26 February 2026

Contact a study center
Step 1 Get in touch with the nearest study center
We have submitted the contact information you provided to the research team at {{SITE_NAME}}. A copy of the message has been sent to your email for your records.
Would you like to be notified about other trials? Sign up for Patient Notification Services.
Sign up

Send a message

Enter your contact details to connect with study team

Investigator Avatar

Primary Contact

  Other languages supported:

First name*
Last name*
Email*
Phone number*
Other language

FAQs

Learn more about clinical trials

What is a clinical trial?

A clinical trial is a study designed to test specific interventions or treatments' effectiveness and safety, paving the way for new, innovative healthcare solutions.

Why should I take part in a clinical trial?

Participating in a clinical trial provides early access to potentially effective treatments and directly contributes to the healthcare advancements that benefit us all.

How long does a clinical trial take place?

The duration of clinical trials varies. Some trials last weeks, some years, depending on the phase and intention of the trial.

Do I get compensated for taking part in clinical trials?

Compensation varies per trial. Some offer payment or reimbursement for time and travel, while others may not.

How safe are clinical trials?

Clinical trials follow strict ethical guidelines and protocols to safeguard participants' health. They are closely monitored and safety reviewed regularly.
Add a private note
  • abc Select a piece of text.
  • Add notes visible only to you.
  • Send it to people through a passcode protected link.