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Early Life Exposures Among Children With Sickle Cell Disease

Early Life Exposures Among Children With Sickle Cell Disease

Recruiting
18-50 years
Female
Phase N/A
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Overview

This study is being conducted to determine the relationship between early childhood exposures, such as Adverse Childhood Experiences, Social Determinants of Health and nutrition/breastfeeding, among children with sickle cell disease, and behavioral interventions aimed to reshape psychological resilience and lifestyle factors towards positive health outcomes.

Description

During year 3 of the award period, 20 mother-infant dyads will be randomly assigned to either a community-based breastfeeding support group or observation. Acceptability to enrollment, intervention adherence for at least 6 months and preliminary effectiveness will be captured. Biomarkers of inflammation, development of asthma and incidences of pain and/or acute chest syndrome will be compared among the intervention and control groups.

Eligibility

Inclusion Criteria:

  • mother of infant with sickle cell disease
  • resides within the city of Birmingham, Alabama or in close proximity

Exclusion Criteria:

  • prescribed teratogenic medications
  • no/limited internet access

Study details
    Sickle Cell Disease
    Adverse Childhood Experiences
    Breastfeeding

NCT05377372

University of Alabama at Birmingham

26 February 2026

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