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cDNA and Residual Disease After Chemoradiotherapy for Locally Advanced Head and Neck Squamous Cell Carcinomas

cDNA and Residual Disease After Chemoradiotherapy for Locally Advanced Head and Neck Squamous Cell Carcinomas

Recruiting
18-80 years
All
Phase N/A
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Overview

The goal of this ancillary clinical trial is to evaluated circulating DNA as a biomarker of residual disease after chemoradiotherapy for locally advanced head and neck squamous cell carninoma.

The main question it aims to answer is :

\- Does circulating DNA (cDNA) be able to detect residual disease 3 months after the end of chemoradiotherapy ? Researchers will compare detection of cDNA at 3-months and objective response (clinical and radiological).

Participants will :

  • be included in the main study (Neck-TAR)
  • have a blood sample 1 and 3-month after the end of treatment

Eligibility

Selection Criteria:

  • Patient included in NeckTAR study
  • Written informed consent signed for NeckTAR-IN study
  • Affiliation to the French social security system

Study details
    Locally Advanced Head and Neck Carcinoma

NCT07178847

Centre Jean Perrin

1 February 2026

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