Overview
A study to create control arms using current and future information in patients with lung cancer that has spread who have already received chemotherapy.
Eligibility
Inclusion Criteria:
1\. \> 18 years of age at the time of informed consent 2. Pathologically confirmed NSCLC 3 .ECOG Performance of \>1 and fit for further systemic therapy on a NCCN approved regimen (within 4 weeks prior or 14 days after starting second line therapy) 4. Life expectancy of more than 3 months 5. Able to understand and sign informed consent \see protocol for cohort specific inclusion criteria\
Exclusion Criteria:
- Unable to provide informed consent
- Actively on a clinical trial of an investigational agent
- Non protocol compliant baseline imaging scan (modality/coverage) prior to index date in patients included after the second or third line therapy has been initiated \see protocol for cohort specific exclusion criteria\ -