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Ultrasound Guided External Oblique and Rectus Abdominis Plane Block (EXORA) on Neuroendocrine Stress Response in Adults Undergoing Umbilical Hernia Surgery

Ultrasound Guided External Oblique and Rectus Abdominis Plane Block (EXORA) on Neuroendocrine Stress Response in Adults Undergoing Umbilical Hernia Surgery

Recruiting
21-65 years
All
Phase N/A

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Overview

This study aims to evaluate the efficacy of ultrasound-guided external oblique and rectus abdominis plane block on the neuroendocrine stress response and postoperative analgesia in adults undergoing umbilical hernia repair.

Description

Umbilical hernias of the abdomen are defined as a non-inguinal, non-hiatal defect in the fascia of the abdominal wall. Surgical stress response refers to the physiologic response to surgery and the hormonal and metabolic changes that follow it.

Fascial plane blocks are gaining attention for perioperative analgesia due to their efficacy and safety profiles. The external oblique and rectus abdominis plane (EXORA) block is an emerging technique that provides a sensory block to the anterolateral abdominal wall, potentially filling gaps left by other commonly used blocks, such as the quadratus lumborum (QLB) or erector spinae plane (ESP) blocks.

Eligibility

Inclusion Criteria:

  • Aged from 21 to 65 years.
  • Both sexes.
  • American Society of Anesthesiologists (ASA) Physical status I and Ⅱ.
  • Schedule for elective umbilical hernia surgery under general anesthesia.

Exclusion Criteria:

  • ASA Ⅲ or Ⅳ.
  • Patients with metabolic abnormalities, e.g., diabetes mellitus.
  • Patients receiving corticosteroids.
  • History of allergies to local anesthetics.
  • Bleeding or coagulation disorders.
  • Anatomical abnormalities.
  • Psychiatric and neurological disorders.
  • Complicated hernial defect (obstructed).
  • Patient refusal.

Study details
    Ultrasound
    External Oblique
    Rectus Abdominis Plane Block
    Neuroendocrine Stress Response
    Umbilical Hernia

NCT07324863

Tanta University

1 February 2026

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