Overview
The purpose of this study is to evaluate the safety, feasibility, and efficacy of vagus nerve stimulation (VNS) paired with mobility training to improve lower extremity function and gait in individuals with chronic ischemic stroke.
Eligibility
Inclusion Criteria:
- Age ≥ 18 years
- Ischemic stroke ≥6 months prior to enrollment.
- Post-stroke lower extremity impairment defined as gait velocity of less than 0.8 m/s on a 10-meter walk test
- Provision of informed consent
Exclusion Criteria:
- Intracerebral Hemorrhage
- Active or prior psychosis or substance abuse within two years.
- Pre-stroke modified Rankin Scale (mRS) 3-5.
- Unable to participate in in-clinic rehabilitation.
- Preexisting neurological disorders affecting gait and mobility, such as Parkinson's disease, Amyotrophic Lateral Sclerosis (ALS), Multiple Sclerosis (MS), dementia, major head trauma.