Overview
The primary objective of this clinical trial is to assess cervical cancer screening participation among under-screened women invited through organized breast cancer screening programs in Switzerland.
This randomized trial will compare three arms:
- Intervention group 1: Sensitization to Cervical Cancer (CC) screening Women will receive an awareness letter explaining the importance of cervical cancer screening, the Swiss recommendations and an invitation to schedule an appointment.
- Intervention group 2: Home-based Human papillomavirus infection (HPV) self-sampling Women will receive a free-of-charge vaginal self-sampling kit for HPV infection
- Observational control group Women selected in the control arm will only be recruited one year following the screening of those in the intervention arm (T0+1), as to not influence Cervical Cancer Screening (CCS) behavior during this period by being reminded of screening recommendations.
Description
Secondary objectives are:
- To identify and compare the association of socio-demographic characteristics with screening participation in all study arms (cf. 3.2 study design).
- To compare the use of primary screening methods (HPV test vs. Papanicolaou test) between study arms.
- To compare prevalence of positive primary screening and triage results between study arms.
- To compare follow-up rates for participants screened positive in both intervention arms.
- To evaluate acceptability of both screening strategies (sensitization vs. home-based).
- To assess the relationship between CCS behavior and Breast Cancer Screening (BCS) behavior.
Eligibility
Inclusion Criteria:
- Women receiving Breast Cancer Screening (BCS) invitation letters in the selected five cantons (Geneva, Bern (francophone), Jura, Neuchâtel, and Vaud)
- Aged 50 to 74 years old
- Not been screened for cervical cancer in the past three years
- Speaking one of the 6 languages of the study (French, German, Italian, and in English, Spanish, and Portuguese)
Exclusion Criteria:
- Prior cervical cancer diagnosis,
- Hysterectomy
- Non consent to participate to the study
- Incapable of judgment or under tutelage
- Pregnancy