Overview
This study will develop a simple index to measure how well the body uses insulin and overall heart and metabolic health in children and teens with obesity. The investigators will use data from wearable devices (like fitness trackers) and glucose monitors, along with lab tests, to learn how activity and glucose relate to metabolic problems.
Description
This is a prospective cohort study to develop a metabolic index for insulin sensitivity and cardiometabolic fitness among children and adolescents with obesity. Adolescent patients undergoing evaluation for bariatric surgery or medical management of wight using GLP-1 agonist therapies will be consented for participation. Participants will be given a wearable fitness device and a continuous glucose monitor. Continuous monitoring will be carried out at three time points: preoperative or prior to starting medication, perioperative or after 3-4 weeks of GLP1 use during early treatment phase, and 3 months post-operatively or 3 months after dose stabilization or discontinuation.
Eligibility
Inclusion Criteria:
- Class 2 and 3 obesity
- Patient in the Adolescent Bariatric Program at Stanford Children's that is eligible for either laparoscopic sleeve gastrectomy or GLP1 Receptor Agonist Therapy
- Willingness to wear a CGM and physiological monitor for the duration of the study.
Exclusion Criteria:
- Hypothalamic and syndromic obesity
- BMI \> 55
- Plan to undergo bariatric surgical procedure other than sleeve gastrectomy
- Prior bariatric surgical procedure
- Active GLP treatment (within past 3 months)
- Unable to read, understand, or complete the informed consent in English or Spanish