Overview

The purpose of this study is to determine if non-steroidal anti-inflammatory (NSAID) use in the postoperative setting increases the risk of acute kidney injury (AKI) in pediatric patients with mild-to-moderate chronic kidney disease (CKD). The investigators hypothesize that there is no increased risk. This will be a limited pilot study within a Pediatric Urology population, intended to inform future work in a larger patient population.

Eligibility

Inclusion Criteria:

• Patients over 18 months of age
• diagnosis of CKD stages 2-3a, confirmed by cystatin C laboratory testing within 6 months of surgery

Exclusion Criteria:

• diagnosis of CKD stage 1 or 4-5
• home medications of angiotensin converting enzyme inhibitors (ACEi, such as lisinopril or captopril) or angiotensin receptor blocker (ARB, such as losartan, valsartan) diuretics, or trimethoprim
• IV contrast in last 30 days
• PMH of renal transplant, diabetes, hypertension, nephrotic syndrome or heart failure, asthma, or hyperthyroidism
• history of hyperkalemia
• recent glucocorticoid exposure
• procedure for oncologic indications
• ongoing viral or fungal infection, or chemotherapy
• allergy to NSAIDs