Overview
The goal of this clinical trial is to learn if a fast-acting brain stimulation treatment called transcranial magnetic stimulation (TMS) can help people with depression and suicidal thoughts. The treatment is non-invasive (does not involve surgery or medications), is given over 5 days, and uses brain imaging (MRI) to guide which part of the brain to target. This study tests whether this treatment is a helpful and practical option for adolescents and young adults who are depressed and have suicidal thoughts.
We want to see if:
- This treatment is feasible and acceptable to patients
- It can reduce depression and suicidal thoughts
- It can lower the chance of going to the hospital
- It affects daily functioning (school, work, relationships)
All participants will undergo 5-days of TMS treatment and complete MRI brain scans before and after treatment. They will return for check-ups after 1 week and 4 weeks.
Eligibility
Inclusion Criteria:
- English speaking
- Able to provide informed consent
- age 15 years or older
- Discharged within the past week from the ED for chief complaint of SI OR recently admitted in urgent health care setting or seen in outpatient clinic for depression-related suicidal ideation
- Meets MDD criteria per the Mini International Neuropsychiatric Interview (MINI)
Exclusion Criteria:
- Unable to consent (due to medical condition, psychosis, substance use, etc)
- Use of benzodiazepines or medications that would interfere with TMS treatment as per PI discretion
- Active substance use or severe substance use that in the opinion of the PI would interfere with study participation
- Untreated, active psychosis
- Female patient who is breastfeeding, pregnant or who is planning a pregnancy during the study
- Participation in any clinical study with exposure to any investigational treatment or product within the previous 30 days, or plan on concurrent participation in other studies
- Contraindications to receiving TMS and/or MRI as determined by screening questionnaires