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RNA Sequencing of Discarded Tracheal Stenosis Tissue to Characterize Cellular and Molecular Pathogenesis

RNA Sequencing of Discarded Tracheal Stenosis Tissue to Characterize Cellular and Molecular Pathogenesis

Recruiting
18-80 years
All
Phase N/A

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Overview

Benign tracheal stenosis is a rare but potentially life-threatening condition, typically resulting from fibroinflammatory scarring. It can be secondary to iatrogenic etiologies such as intubation or tracheostomy , as well as autoimmune diseases and being idiopathic. Patients typically undergoes endoscopic or surgical interventions to open up the airways. This project will analyze resected or biopsied tissue from patients with benign tracheal stenosis to define disease-specific RNA expression profiles.

Eligibility

Inclusion Criteria:

  • Patients with benign tracheal stenosis

Exclusion Criteria:

  • Malignancy. active infection

Study details
    Tracheal Stenosis
    Subglottic Stenosis

NCT07258784

University of Maryland, Baltimore

1 February 2026

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