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Pilot Study of Line-Field Confocal Optical Coherence Tomography for Detection of Mohs Micrographic Surgery Margins of Basal Cell Carcinomas

Pilot Study of Line-Field Confocal Optical Coherence Tomography for Detection of Mohs Micrographic Surgery Margins of Basal Cell Carcinomas

Recruiting
18 years and older
All
Phase N/A

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Overview

To assess the feasibility and provide information on the utility of noninvasive line field confocal optical coherence tomography (LC-OCT) for the presurgical assessment of Mohs micrographic surgery sites in patients undergoing removal of cutaneous basal cell carcinomas (BCC).

Eligibility

Inclusion Criteria:

  • Age ≥ 18 years
  • Participant must understand the investigational nature of this study and provide written consent prior to receiving any study-related procedure.
  • Participant must be clinically eligible for Mohs surgery as determined by their referring dermatologist and the Mohs surgeon.
  • The participant must have a BCC with superficial histology or a BCC with multiple histological features that also include superficial histology, which is appropriate for Mohs surgery.

Exclusion Criteria:

  • Known or reported allergy to mineral oil, the optical agent used during imaging.
  • Uncontrolled intercurrent illness including, but not limited to, ongoing or active infection, symptomatic congestive heart failure, unstable angina pectoris, cardiac arrhythmia, or psychiatric illness/social situations that would limit compliance with study requirements.
  • . Any condition which in the investigator's opinion deems the subject an unsuitable candidate to undergo imaging procedure.
  • Unwilling or unable to follow protocol requirements

Study details
    Basal Cell Carcinoma

NCT07182240

Roswell Park Cancer Institute

1 February 2026

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