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Aphasia Physical EXercise Study: Randomized Trial

Aphasia Physical EXercise Study: Randomized Trial

Recruiting
18-80 years
All
Phase N/A

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Overview

The goal of this clinical trial is to evaluate the effects of a high-intensity exercise program on recovery in individuals with post-stroke aphasia. The high-intensity exercise program has been specifically designed for individuals with post-stroke aphasia and includes an interval training full-body workout, which can increase cardiovascular fitness, improve muscle strength and motor performance, and maximize cognitive and language gains. The main question this study aims to answer is:

• Does participation in a high-intensity exercise program lead to changes in physical health, language, cognitive, motor recovery, psychological and/or psychosocial domains?

Participants will be randomly assigned to either a high-intensity exercise program (target intervention) or a low-intensity exercise program (control intervention) delivered over 12-weeks in a group setting.

Outcome measures will be collected once immediately after the intervention period and once during the following 12-week maintenance period to capture short- and long-term effects of the exercise program.

Eligibility

Inclusion Criteria:

  • Aphasia following ischemic or hemorrhagic stroke
  • Aphasia as determined by a standardized language test (Western Aphasia Battery Aphasia Quotient \< 93.8 at study intake)
  • At least 6 months from the last stroke
  • Proficient in English before the stroke
  • At least 8 years of education
  • Between the ages of 18 and 80
  • Independent with ambulation without a device (single-point cane accepted)
  • Medically stable with no contraindications to participate in regular physical exercise as determined by the patients' own primary care provider or other treating provider.

Exclusion Criteria:

  • Prior history of dementia, neurologic illness (other than stroke), or recent (last 3 years) substance abuse
  • Significant visual or hearing disabilities (e.g., neglect, uncorrected visual or hearing loss) that interfere with testing
  • Self-report uncontrolled cardiorespiratory and/or metabolic disorders incompatible with exercise

Study details
    Aphasia
    Acquired
    Aphasia
    Aphasia
    Fluent
    Aphasia
    Non-fluent
    Aphasia Following Cerebral Infarction
    Aphasia Following Nontraumatic Intracerebral Hemorrhage

NCT07281313

University of California, Berkeley

1 February 2026

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FAQs

Learn more about clinical trials

What is a clinical trial?

A clinical trial is a study designed to test specific interventions or treatments' effectiveness and safety, paving the way for new, innovative healthcare solutions.

Why should I take part in a clinical trial?

Participating in a clinical trial provides early access to potentially effective treatments and directly contributes to the healthcare advancements that benefit us all.

How long does a clinical trial take place?

The duration of clinical trials varies. Some trials last weeks, some years, depending on the phase and intention of the trial.

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Compensation varies per trial. Some offer payment or reimbursement for time and travel, while others may not.

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Clinical trials follow strict ethical guidelines and protocols to safeguard participants' health. They are closely monitored and safety reviewed regularly.
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