Overview
This prospective, randomized, double-blind clinical trial aims to evaluate the analgesic efficacy of intravenous magnesium sulfate in women presenting to the emergency department with acute dysmenorrhea. Participants will be randomized into two groups receiving either 2 ampoules of magnesium sulfate or intravenous dexketoprofen. Pain levels will be assessed using the Visual Analog Scale (VAS) before and after treatment.
Description
This prospective, randomized, double-blind clinical trial is designed to evaluate the analgesic effectiveness of intravenous magnesium sulfate in women aged 18 to 35 years presenting to the emergency department with acute dysmenorrhea. Participants will be randomly assigned to one of two treatment groups: 2 ampoules of magnesium sulfate or intravenous dexketoprofen.
All medications will be diluted in 100 ml of normal saline and administered intravenously over 15 minutes. Pain intensity will be assessed using the Visual Analog Scale (VAS) before treatment and 1 hour after administration. Secondary outcomes include patient satisfaction, vital sign changes, and adverse effects.
The study aims to compare the analgesic efficacy and safety profile of intravenous magnesium sulfate with that of a standard nonsteroidal anti-inflammatory drug (dexketoprofen) in the management of acute dysmenorrhea.
Eligibility
Inclusion Criteria:
Female patients aged 18 to 35 years
Presenting to the obstetrics and gynecology emergency department with a diagnosis of primary dysmenorrhea
Having regular menstrual cycles within the last 6 months
Having a Visual Analog Scale (VAS) pain score of ≥6 at emergency admission
Providing written informed consent for participation in the study
Exclusion Criteria:
Patients with secondary dysmenorrhea or underlying gynecological pathology
Pregnancy or breastfeeding
Use of analgesics or muscle relaxants within the last 3 days
Known allergy to magnesium sulfate or dexketoprofen trometamol
History of renal failure, cardiac arrhythmia, or serious systemic disease
Inability to assess pain due to mental disability or communication disorder
Failure to provide informed consent for participation in the study