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Effect of Donor Diabetes and Other Factors on Corneal Transplant Endothelial Cell Loss and Success at 5 Years

Effect of Donor Diabetes and Other Factors on Corneal Transplant Endothelial Cell Loss and Success at 5 Years

Recruiting
30-93 years
All
Phase N/A
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Overview

This multi-center clinical trial is designed to assess the association of diabetes in a cornea donor with transplant success and loss of endothelial cells 5 years following Descemet membrane endothelial keratoplasty (DMEK). Study eyes are assigned to receive either a cornea from a donor without diabetes or a cornea from a donor with diabetes in a masked fashion.

Eligibility

Inclusion Criteria:

  • Willing to return to the study site for follow up at 3 and 5 years after a Descemet membrane endothelial keratoplasty procedure
  • Fluent in English or Spanish
  • Willing to have fingerstick blood sample collected to determine HbA1c level
  • Participated and completed 12-month follow-up in the DEKS study for one or both eyes or a DEKS participant that had a study eye regraft prior to the 12-month visit.

Exclusion Criteria:

  • Lack cognitive capacity such that consent could not be provided.

Study details
    Fuchs Endothelial Corneal Dystrophy
    Corneal Endothelial Decompensation

NCT07217249

Case Western Reserve University

1 February 2026

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