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Combined Effects of INF and OEP in Patients With Diabetic Peripheral Neuropathy

Combined Effects of INF and OEP in Patients With Diabetic Peripheral Neuropathy

Recruiting
50-75 years
All
Phase N/A

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Overview

DPN often leads to balance issues, sensory deficits, and chronic pain, which can severely impact daily functioning and independence. INF therapy aims to improve nerve blood flow and alleviate neuropathic symptoms through manual techniques, while the Otago Exercise Program focuses on enhancing strength and balance to reduce fall risk. By comparing these two interventions, this study seeks to identify effective strategies that can improve balance, reduce pain, and enhance the quality of life for individuals suffering from DPN

Description

This study addresses a gap in existing literature by comparing the effects of intraneural facilitation therapy and Otago exercise in improving balance, pain and QOL among DPN patients. While both Intraneural Facilitation (INF) therapy and the Otago Exercise Program have been acknowledged for their individual benefits, their comparative effectiveness in the context of diabetic peripheral neuropathy (DPN) has not been adequately explored. This study aims to bridge this gap by examining which intervention more effectively improves quality of life, reduces pain, and enhances balance in DPN patients, thus providing essential insights for optimizing treatment approaches.

Eligibility

Inclusion Criteria:

  • Age 50-75years
  • Both male and female patients will be included in the study
  • Patient with type 2 diabetes mellitus (diagnosed by the physician)
  • Patients with a score ≥ 4 on DN4 scale
  • Patients have a score on the Timed Up-and-Go (TUG) test of less than 15 s
  • Able to walk at least 10 meters long

Exclusion Criteria:

  • Patient with presence of any other systemic disease rather than diabetes such as end-stage renal failure, uncontrolled hypertension, severe dyslipidemia, chronic liver disease, autoimmune disease, advanced chronic obstructive pulmonary disease etc
  • Patients with documented active alcohol or drug misuse
  • Patient with total or partial amputation of lower extremities
  • Participants will be also excluded if they were morbidly obese or if pregnant (self-reported)
  • Patient with active inflammations or other inflammatory neuropathies including chronic inflammatory demyelinating polyneuropathy, proximal diabetic neuropathy, chemotherapy-induced peripheral neuropathy, autonomic neuropathies, or other neuropathies not associated with DM such as B12 deficiency

Study details
    Diabetic Peripheral Neuropathy

NCT07274735

Riphah International University

1 February 2026

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