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Effects of Moderate/Severe Traumatic Brain Injury in the Subacute or Chronic Phase on Locomotor Strategies Involved in Navigation in Complex Virtual Environments

Effects of Moderate/Severe Traumatic Brain Injury in the Subacute or Chronic Phase on Locomotor Strategies Involved in Navigation in Complex Virtual Environments

Recruiting
18-55 years
All
Phase N/A

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Overview

While clinical assessment of locomotor function in this population is carried out using tasks involving walking in a straight line without any obstacles, it does not take into account ecological situations (i.e., situations comparable to real-life situations) in which the person interacts with their environment, such as walking down a street with other pedestrians, which is fundamental to everyday life. This research therefore aims to study the social navigation skills during locomotion of people who have suffered a moderate or severe head injury in the chronic phase in more ecological tasks. This will provide a better understanding of the difficulties encountered by these patients during locomotor interactions in everyday life.

Eligibility

Inclusion Criteria for Traumatic Brain Injury group :

  • 18 ≤ Age ≤ 55 years old
  • Male/female
  • Having suffered a first non-penetrating head injury
  • Moderate to severe severity with initial Glasgow Coma Scale score 5\<GCS\<13
  • In the subacute or chronic phase (≥ 3 months at the date of the experiment, relative to the date of the injury)
  • Able to walk (10WMT speed ≥ 0.8 m/s, able to walk at least 20 m without technical or human assistance, PM ≥ 300 m)
  • Able to maintain dynamic balance while standing (TUG\<16s)
  • Able to answer simple questionnaires, according to the investigator's judgment
  • Having given their free, informed, expressed (written) consent
  • Registered with a social security system
  • Individuals under legal protection measures such as guardianship may be eligible

Inclusion Criteria for healthy control group :

  • 18 ≤ Age ≤ 55 years old
  • Male/female
  • Able to walk (≥ 0.8 m/s, able to walk at least 20 m without technical or human assistance, PM ≥ 300 m)
  • Able to answer simple questionnaires, according to the investigator's judgment
  • Having given free, informed, expressed (written) consent
  • Registered with a social security system

Exclusion Criteria specific to patients in the traumatic brain injury group :

\- Person under legal protection (excluding guardianship) or unable to express consent

Exclusion Criteria for both groups :

  • Severe patho-psychiatric care underway, which may impact the conduct of the protocol, at the investigator's discretion
  • Presence of neurological signs suggestive of a neurodegenerative disease responsible for gait disturbance (Parkinson's syndrome, Alzheimer's disease, etc.)
  • Individuals with musculoskeletal disorders that impact their locomotor abilities
  • Presence of uncontrolled epilepsy at the time of inclusion
  • Presence of visual impairments that make experimentation impossible, at the discretion of the investigator
  • Pregnant, parturient, or breastfeeding women
  • Participants in another ongoing research protocol involving human subjects

Exclusion Criteria for healthy control group :

  • Presence of fatigue, trauma, or a condition affecting mobility, posture, balance, or walking
  • Persons deprived of their liberty by a judicial or administrative decision
  • Persons deprived of their liberty by judicial or administrative decision
  • Persons under legal protection (guardianship, curatorship, judicial protection) or unable to express their consent
  • Persons undergoing severe psychiatric treatment or admitted to a health or social care facility for purposes other than research.

Study details
    Traumatic Brain Injury

NCT07230002

Pôle Saint Hélier

1 February 2026

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