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Comparison Between Two Methods for Renal Stone Treatment Mini Percutaneous Nephrolithotomy and Flexible Ureteroscopy With Suction Sheath

Comparison Between Two Methods for Renal Stone Treatment Mini Percutaneous Nephrolithotomy and Flexible Ureteroscopy With Suction Sheath

Recruiting
18 years and older
All
Phase N/A

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Overview

This study aims to compare the efficacy and safety of two modern, minimally invasive surgical techniques for the removal of kidney stones: Mini-Percutaneous Nephrolithotomy (Mini-PCNL) and Flexible Ureteroscopy (FURS) with Flexible and navigable suction sheath

The primary objective is to determine which procedure results in a higher stone-free rate, as measured by post-operative imaging. Secondary objectives include comparing operative time, hospitalization length andcomplication rates between the two treatment groups.

Patients with two to three centimeter kidney stones who are candidates for either procedure will be randomly assigned to undergo either Mini-PCNL or suctioning FURS. The outcomes will be critically assessed to help establish a higher level of evidence for guiding surgical management of kidney stones.

Description

Mini-PCNL involves creating a small tract from the skin on the back directly into the kidney, through which a miniature nephroscope is passed to visualize and remove stones. Flexible Ureteroscopy is performed by passing a thin, flexible scope through the natural urinary passage (urethra and ureter) into the kidney. The specific FURS technique in this study utilizes a specialized scope with integrated suction, which is theorized to improve stone fragment clearance.

Eligibility

Inclusion Criteria:

  • Adult patients aging 18 years old or more.
  • Patients with renal stones between 2-3 cm in size confirmed by CT scan.

Exclusion Criteria:

  • Patients with previous ureteric injury.
  • Patients with uncontrolled diabetes mellitus or hypertension.
  • Patients with uncontrolled hepatic dysfunction.
  • Patients with uremia or renal failure.
  • Pregnant patients.
  • patients with active urinary tract infection.
  • Patients with bleeding tendency or uncontrolled coagulopathy.
  • Patients with congenital anomalies as horse-shoe kidney and pelvi-ureteric junction obstruction.

Study details
    Stone;Renal
    Stone
    Urinary
    Stone
    Kidney
    Stone Clearance

NCT07306819

Ain Shams University

1 February 2026

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