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Blood Pressure Control With Thiazide Diuretics in Peritoneal Dialysis Patients

Blood Pressure Control With Thiazide Diuretics in Peritoneal Dialysis Patients

Recruiting
18 years and older
All
Phase 4
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Overview

To evaluate the blood pressure lowering effects of thiazide diuretics in patients on peritoneal dialysis

Description

This prospective, single-center treatment-withdrawal crossover study enrolled 10 patients on chronic peritoneal dialysis (PD) and uncontrolled hypertension (SBP \>140 mmHg and/or DBP \>90 mmHg).

Following written informed consent, participants entered the treatment arm, receiving oral hydrochlorothiazide once daily on top of their standard of treatment for 90 days. This was followed by a 14-day washout period, after which participants entered a 90-day control period.

Eligibility

Inclusion Criteria:

  • Patients on chronic peritoneal dialysis, with uncontrolled hypertension (SBP \>140 mmHg and/or DBP \>90 mmHg)

Exclusion Criteria:

  • Patients with a life expectancy of less than 3 months, planned conversion to hemodialysis, or scheduled kidney transplantation within 3 months

Study details
    Hypertension
    Peritoneal Dialysis
    End Stage Kidney Disease (ESRD)

NCT07271420

Chinese University of Hong Kong

31 January 2026

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