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Efficacy and Safety of MET097 Once-Weekly in People With Overweight or Obesity

Efficacy and Safety of MET097 Once-Weekly in People With Overweight or Obesity

Recruiting
18-99 years
All
Phase 3
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Overview

This study investigates the efficacy and safety of once weekly injectable MET097 in adult participants with obesity or overweight with weight-related comorbidities excluding T2D. This trial will last for a duration of 84 weeks. The primary endpoint will be assessed after 64 weeks of treatment with the secondary at 84 weeks.

Eligibility

Inclusion Criteria:

  • BMI ≥ 30 kg/m2 or BMI ≥ 27.0 kg/m2 to \<30.0 kg/m2 and presence of at least 1 of the following weight- related comorbidities: Hypertension, dyslipidemia, obstructive sleep apnea, or cardiovascular disease)

Exclusion Criteria:

  • Have any form of diabetes
  • Have a self-reported body weight change \> 5 kg (11 pounds) within 3 months prior to Screening
  • Personal or family history of medullary thyroid carcinoma (MTC) or multiple endocrine neoplasia syndrome type 2 (MEN-2)
  • History of chronic pancreatitis or presence of acute pancreatitis within the past 180 days prior to the Screening visit; or active/current, symptomatic gallbladder disease

Study details
    Obesity and Overweight

NCT07311850

Metsera, a wholly owned subsidiary of Pfizer

31 January 2026

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A clinical trial is a study designed to test specific interventions or treatments' effectiveness and safety, paving the way for new, innovative healthcare solutions.

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Clinical trials follow strict ethical guidelines and protocols to safeguard participants' health. They are closely monitored and safety reviewed regularly.
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