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Clindamycin as Antimicrobial Treatment for Streptococcus Spp. PeRiprosthetic Infection

Clindamycin as Antimicrobial Treatment for Streptococcus Spp. PeRiprosthetic Infection

Recruiting
18 years and older
All
Phase N/A
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Overview

Clindamycin is an antibiotic with several advantages: high oral bioavailability and good bone and joint penetration. In France, it is a recommended drug for other types of Streptococcus spp. osteoarticular infections and can be used as an alternative to amoxicillin for periprosthetic infections, including when implants are retained.

The hypothesis of this study is that clindamycin is no less effective than other drugs commonly used to treat periprosthetic Streptococcus spp. infections.

The primary objective of this study is to evaluate the success rate of Streptococcus spp. periprosthetic joint infections treated with clindamycin compared to other antibiotic treatments.

Eligibility

Inclusion Criteria:

  • Adult patient (aged 18 years or older) at the time of surgery for infection
  • Probable or proven periprosthetic infection with Streptococcus spp. according to EBJIS diagnostic criteria
  • Patient operated on in one of the associated centers between 2013 and 2024

Exclusion Criteria:

  • Patient who underwent joint resection or amputation
  • Patient who was treated with suppressive antibiotic therapy (defined as antibiotic treatment lasting more than 6 months) which was decided upon prior to surgery

Study details
    Streptococcus Infection

NCT07335627

University Hospital, Strasbourg, France

31 January 2026

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