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Spiritual Care or Psychotherapy Versus Palliative Care Alone in Patients With Non-Curative Malignancies

Spiritual Care or Psychotherapy Versus Palliative Care Alone in Patients With Non-Curative Malignancies

Recruiting
18 years and older
All
Phase 3

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Overview

This phase III clinical trial will evaluate the impact on survival of adding chaplain-provided spiritual care or psychotherapy/meditation to standard-of-care (SOC) and palliative measures, plus chemotherapy if recommended, and comparing it with SOC and palliative measures, plus chemotherapy if recommended, in patients with non-curative malignancies. The Palliative Care Department at Houston Methodist Hospital provides essential services to patients diagnosed with advanced cancer by sharing information and resources about symptom management, pain treatment and planning for the future. It is also recognized that chaplaincy-based spiritual care of patients can be a valuable part of interdisciplinary interventions in oncology.

Eligibility

Inclusion Criteria:

Patients are eligible to be included in the trial only if all of the following criteria apply

  • The patient provides written informed consent for the trial.
  • Male or female ≥18 years of age on the day of informed consent signing.
  • Histologically confirmed metastatic disease with life expectancy of one year or less.
  • Eastern Cooperative Oncology Group (ECOG) performance status of 0 to 3.
  • Willing and able to comply with the protocol for the duration of the trial including undergoing scheduled visits and interventions.

Exclusion Criteria:

Patients are excluded from the trial if any of the following criteria apply:

  • Known psychiatric or substance abuse disorders that would interfere with cooperation with the requirements of the trial. If a patient develops a psychiatric disorder after baseline, he/she will not be taken off the trial.
  • Mobility limitations that would interfere with cooperation with the requirements of the trial.
  • Confirmed positive pregnancy test in women of child bearing potential.

Study details
    Cancer

NCT07290491

The Methodist Hospital Research Institute

31 January 2026

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