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A Study Evaluating the Safety and Tolerability of Artesunate in Patients With Pulmonary Arterial Hypertension

A Study Evaluating the Safety and Tolerability of Artesunate in Patients With Pulmonary Arterial Hypertension

Recruiting
18-60 years
All
Phase 1
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Overview

This is a 20-week, Phase 1, single-center, open-label, dose-escalation study evaluating the safety and tolerability of daily oral artesunate in patients with PAH.

Eligibility

Inclusion Criteria

  • Each participant must meet the following criteria to be enrolled in this study:
  • Adults aged 18 to 75 years.
  • WHO functional class I, II/III despite treatment with maximally tolerated doses of 2 or more treatment modalities including PDE5 inhibitors, guanylate cyclase stimulators, endothelin receptor antagonists, and prostanoids when appropriate.

Exclusion Criteria

  • Participants who meet any of the following criteria will be excluded from the study.
  • Participants with serious concomitant morbidity per investigator assessment.

Study details
    Pulmonary Arterial Hypertension (PAH)

NCT06872112

Joseph C. Wu

31 January 2026

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