Overview
This is a pilot study to evaluate the feasibility, image quality, and procedural utility of a novel spectral CT technique using Canon Medical's 4D CT system during image-guided interventional oncology procedures
Description
The aims of this study are:
- Demonstrate the feasibility of acquisition and image quality of intra-arterial spectral CT images obtained during mapping arteriography prior to trans arterial radioembolization (TARE) for liver cancer treatment.
- Assess the procedural utility of Spectral CT images as part of the TARE workflow, such as hepatopulmonary shunt fraction estimation, lesion identification, prediction of tumor: normal liver (T:N) dose ratio, and dose distribution
- Investigate the feasibility, safety, and image quality of Spectral CT images obtained during tumor ablation.
- Explore the feasibility of assessing physiologic tissue changes using Spectral CT (effective anatomic number maps)
- During ablation with microwave, cryoablation, and irreversible electroporation in an ex vivo model
- For image-guided tumor ablation, such as lesion identification, probe placement, and ablation monitoring.
Eligibility
Inclusion criteria:
- Age \> or = 18 years
- Tumor in an area without prior surgical or ablative therapy
- At least 1 tumor greater than 1.5 cm in greatest diameter
Exclusion criteria:
- Not eligible for indicated procedure.
- BMI \> 35
- Prior surgery.