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Evaluation of Efficacy and Safety of AR882 and XOI Co-administration in Uricase Treatment Failed Patients

Evaluation of Efficacy and Safety of AR882 and XOI Co-administration in Uricase Treatment Failed Patients

Recruiting
18-85 years
All
Phase 2
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  • Simplified (AI rewritten)

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Overview

This study will assess the effect of AR882 and XOI co-administration on sUA lowering as well as reducing tophus burden in the population that has failed uricase treatment (eg., pegloticase). Failed uricase treatment is defined as having an inherent intolerance, anaphylaxis, infusion reaction, antibody development, and/or at least one sUA level that rose to greater than 6 mg/dL while on therapy.

Eligibility

Inclusion Criteria:

  • History of uncontrolled gout
  • Presence of ≥1 clinically visible tophus
  • Last uricase infusion occurred ≥3 months
  • Body weight no less than 50 kg
  • Serum creatinine must be \< 3.0 mg/dL and estimated CLcr ≥ 40 mL/min

Exclusion Criteria:

  • Malignancy within 5 years, except for successfully treated basal or squamous cell carcinoma of the skin
  • Pregnant or breastfeeding
  • History of symptomatic kidney stones within the past 6 months
  • Received pegloticase, rasburicase or other experimental uricases within the last 3 months

Study details
    Gout
    Gouty Arthritis
    Hyperuricemia
    Gout Chronic
    Refractory Gout
    Uncontrolled Gout
    Tophaceous Gout

NCT07116746

Arthrosi Therapeutics

31 January 2026

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