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Clinical Application of the Effect of Respiratory Muscles Electrical Stimulation on Weaning in Patients With Difficult Weaning of the Mechanical Ventilation

Clinical Application of the Effect of Respiratory Muscles Electrical Stimulation on Weaning in Patients With Difficult Weaning of the Mechanical Ventilation

Recruiting
18 years and older
All
Phase N/A
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Overview

This trial evaluates whether transcutaneous diaphragmatic/phrenic nerve stimulation (TEDS), abdominal functional electrical stimulation (abFES), or their combination, accelerates and improves the quality of weaning from prolonged invasive mechanical ventilation (IMV), compared with standardized ICU care with sham stimulation.

Eligibility

Inclusion Criteria:

  • Invasive mechanical ventilation ≥21 days for PMV; expected ≥48 h ICU stay. Eligible for standardized weaning protocol and SBT assessment. Informed consent by participant or legally authorized representative.

Exclusion Criteria:

  • Non-screenable/unstable arrhythmia or hemodynamics; refractory hypoxemia/hypercapnia.

Pacemaker/ICD not shieldable; seizure disorder uncontrolled. Recent abdominal surgery or skin breakdown at electrode sites; BMI\>35; pregnancy.

Prone positioning; continuous deep neuromuscular blockade; investigator deems unsuitable.

Study details
    Mechanical Ventilation

NCT07199036

Capital Medical University

31 January 2026

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