Overview
Patients undergoing hemodialysis (HD) frequently exhibit elevated serum uric acid (SUA) levels, which are associated with cardiovascular risks, joint issues, and diminished quality of life (QoL). Aerobic exercise has been shown to improve cardiovascular health and reduce SUA levels in various populations, suggesting potential benefits for HD patients.
Objective: This study aimed to investigate the impact of aerobic exercise on serum uric acid (SUA) levels, functional capacity, and quality of life (QoL) in patients undergoing hemodialysis (HD).
Methods: This randomized controlled trial will recruit 32 participants, aged 40-60, undergoing HD. The intervention group (Group A) will participate in a structured 6-week aerobic exercise program, while the control group (Group B) will receive only conventional physical therapy. Pre- and post-intervention assessments included SUA levels, the Six-Minute Walk Test (6MWT), and the Kidney Disease Quality of Life Short Form (KDQOL-SF™)
Description
32 Subjects of both genders will participate in this study at El-khazendara Hospitals with age ranged between (40-60) years old. They will receive a comprehensive verbal and written explanation of the study, including its objectives, procedures, and potential benefits.
participants will randomly assigned into two equal groups using a sealed-envelope randomization method to ensure unbiased allocation.
- Group A (study Group): 16 HD patients receiving a conventional physical therapy program (breathing, stretching, and lower limb circulatory exercises) plus the aerobic exercise program.
- Group B (Control Group): 16 HD patients receiving only the conventional physical therapy program.
6-weeks of aerobic exercise program (3 sessions per week, 20-45 minutes each session)
Outcome measures include:
- Serum Uric Acid: Measured using an automated biochemistry analyzer, with results reported in mg/dL.
- Functional Capacity: Assessed using the Six-Minute Walk Test (6MWT), a validated tool used to evaluate exercise tolerance and endurance in clinical populations.
- Quality of Life:Measured using the Kidney Disease Quality of Life Short Form (KDQOL-SF™) Arabic Version, which assesses various domains related to both physical and mental health.
Eligibility
Inclusion Criteria:
- Hemodialysis patients aged 40-60years
- Patients are medically stable and able to participate in physical activity.
- Participants are able to understand the commands.
- Participants must be stable on hemodialysis for at least 3 months.
Exclusion Criteria:
- Patients with significant cardiovascular or respiratory diseases, or other conditions that could impair their ability to exercise.
- Severe cognitive impairment or psychiatric conditions that could interfere with study participation.
- patients with acute medical conditions.