Overview
The goal of this clinical trial is to learn if the six-month supplementation with sirtuin activators can affect metabolism in 40-to-65-year old women with increased body weight. The main questions it aims to answer are:
Does sirtuin activators affect lipid and carbohydrate metabolism? Does sirtuin activators affect oxydative stress, immune functions and cell ageing?
Researchers will compare sirtuin activators to a placebo (a look-alike substance that contains no drug) to see if drug sirtuin activators works to improve metabolic status.
Participants will:
Take sirtuin activators or a placebo every day for 6 months. Visit the university once every 3 months for checkups and tests.
Eligibility
Inclusion Criteria:
- females
- age: 40-65 years
- overweight or obese: BMI \>25 kg/m2
Exclusion Criteria:
- males
- BMI \< 25 kg/m2
- sirtuin activators administration for 3 months prior to study
- pregnancy or breastfeeding
- recent dieting or being on calorie restricted diet
- receiving pharmacotherapy to treat obesity, diabetes or hyperlipidemia
- post-bariatric surgery
- diabetes
- cancer
- chronic kidney, liver or autoimmune diseases
- alcohol addiction