Overview

The purpose of this study is to investigate the efficacy and safety of different retatrutide dose escalation schemes in participants without type 2 diabetes who have obesity or overweight. Participation in the study will last about 113 weeks.

Eligibility

Inclusion Criteria:

• Have a Body Mass Index (BMI) at screening
  • ≥ 30 kilogram per square meter (kg/m2) OR
  • ≥ 27 kg/m2 with presence of at least one of the following weight-related conditions at screening: high blood pressure, abnormal levels of lipid, obstructive sleep apnea, heart disease
• Have at least one unsuccessful attempt to lose weight by dieting

Exclusion Criteria:

• Have a self-reported change in body weight \>5 kilograms (kg) (11 pounds) within 90 days before screening
• Have a prior or planned surgical treatment for obesity
• Have type 1 diabetes or type 2 diabetes
• Have a family or personal history of medullary thyroid carcinoma (MTC) or multiple endocrine neoplasia syndrome type 2 (MEN-2)
• Have had within the past 90 days before screening:
  • heart attack
  • stroke
  • hospitalization for unstable angina or heart failure
• Have New York Heart Association Functional Classification Class IV congestive heart failure
• Have a history of chronic or acute pancreatitis
• Have taken weight loss drugs, including over-the counter medications within 90 days prior to screening