Overview
The investigators will examine the effects of dynamic light therapy on circadian rhythms in delirious intensive care unit (ICU) patients. In a randomized controlled trial (RCT), they will investigate the effects of a specific light algorithm on rhythms of serum melatonin, clock gene expression, the proteome, and metabolome, compared to standard hospital lighting, supported by the data science algorithms to improve vital-based algorithms with light interventions.
Eligibility
Inclusion Criteria:
- Patient capable of giving consent or additionally existing legal caregiver or authorized/spouse representative in case of non-consenting patients in the intensive care unit
- Male and female patients with age ≥ 18 years
- Expected intensive care unit stay ≥ 2 days
- Positive delirium during and up to a maximum of 30 days after study inclusion (determined by CAM-ICU, at least once per shift)
Exclusion Criteria:
- Participation in other clinical studies during the study period and ten days before
- Previous ICU treatment during the current hospital stay
- Patients with psychiatric diseases
- Patients with a history of stroke and known severe residual cognitive deficits
- Patients with a history of cardiopulmonary arrest or pulseless electric activity with cardiopulmonary resuscitation followed by therapeutic hypothermia during entire hospital stay
- Amaurosis
- History of sleep-related breathing disorders
- History or suspicion of hypoxic brain damage
- History or suspicion of elevated intracranial pressure in the last 7 days before study inclusion
- Patient has a power of attorney or patient's provision, where he/she refuses participation in any clinical trial
- The informed consent of the patient or the subject's legally acceptable representative can't be obtained in time
- History of photoallergic reactions or history of visually triggered seizures
- Severe eye diseases (e.g. retinopathy, glaucoma) or high sensitivity to bright light
- Patients with liver cirrhosis
- Patients with a probability of survival \<24h
- Optic neuritis within the last 3 months
- Travel across two time zones within 3 months prior to study screening
- Women who are pregnant, have a positive pregnancy test, are breastfeeding or plan to become pregnant during the course of this clinical trial
- Therapy-refractory blood coagulation disorder and inability to consent are exclusion criteria for a muscle biopsy