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Post-Market Clinical Investigation Plan- Collagen Dural Regeneration Matrix (DuraMatrix-Onlay Plus)

Post-Market Clinical Investigation Plan- Collagen Dural Regeneration Matrix (DuraMatrix-Onlay Plus)

Recruiting
18 years and older
All
Phase N/A

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Overview

Monitoring the Use of Collagen Dural Regeneration Matrix (DuraMatrix-Onlay Plus) in the Postmarket Phase.

Description

A prospective, post-market, open label clinical study at a maximum of 8 sites, with an enrollment of 118 subjects. The primary endpoint of the study will be the rate of revision surgery. The presence of adverse events will be evaluated at each follow-up time point i.e. CSF leak, infection and Pseudomeningocele. Patients will have a follow-up evaluation at least at 8 weeks post initial surgery date (which align with the approximate resorption time of the device) where possible and as deemed necessary by a clinician.

No original patient records or personal identifying information will be disclosed to Collagen Matrix.

Eligibility

Inclusion Criteria:

  • The general population will be included in the study where a dura substitute is required for the repair of dura mater.

Exclusion Criteria:

  • Patients that have conditions which are contraindicated per the instructions for use (IFU) would be excluded.

Study details
    Repair of Dura Mater

NCT06802133

Collagen Matrix

21 October 2025

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