Overview
The main purpose of this study is to determine the effect of Vimseltinib dosing on breast cancer resistance protein (BCRP) and organic-anion-transporting polypeptide 1 B1 (OAT1PB1) activity by using rosuvastatin in healthy male participants. This study will also evaluate the safety and tolerability when vimseltinib is co-administered with rosuvastatin in healthy male participants. This study will last approximately 26 days.
Eligibility
Inclusion Criteria:
- Participants are in good general health, as required by the protocol and as determined by Principal Investigator.
- Body mass index (BMI) from 18 to 32 kilogram per square meter (kg/m^2).
- Adequate organ function and blood and urine tests, as required by the protocol and as determined by Principal Investigator.
Exclusion Criteria:
- History or presence of clinically significant diseases of the neurological, dermatological, renal, hepatic, gastrointestinal, cardiovascular, or musculoskeletal systems or history or presence of clinically significant psychiatric, immunological, endocrine, or metabolic disease as determined by Principal Investigator.
- Unwilling or unable to comply with the requirements of the protocol.
- Determined by Principal Investigator to be unsuitable to participate in the study for any other reason.